Ventricular Tachycardia as a Complication of Ledipasvir and Sofosbuvir Treatment for HCV Infection

We experienced two patients with serious arrhythmias associated with the administration of ledipasvir (LDV) and sofosbuvir (SOF). Neither patient took amiodarone, an agent for which concomitant use is prohibited. One patient was 82 years old and hypertensive; the other was 72 years old and had no ca...

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Autores principales: Nirei, Kazushige, Nakamura, Hitomi, Matsuoka, Shunichi, Yamana, Yoichiro, Yoda, Shunichi, Hirayama, Atsushi, Moriyama, Mitsuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5457921/
https://www.ncbi.nlm.nih.gov/pubmed/28381744
http://dx.doi.org/10.2169/internalmedicine.56.7948
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author Nirei, Kazushige
Nakamura, Hitomi
Matsuoka, Shunichi
Yamana, Yoichiro
Yoda, Shunichi
Hirayama, Atsushi
Moriyama, Mitsuhiko
author_facet Nirei, Kazushige
Nakamura, Hitomi
Matsuoka, Shunichi
Yamana, Yoichiro
Yoda, Shunichi
Hirayama, Atsushi
Moriyama, Mitsuhiko
author_sort Nirei, Kazushige
collection PubMed
description We experienced two patients with serious arrhythmias associated with the administration of ledipasvir (LDV) and sofosbuvir (SOF). Neither patient took amiodarone, an agent for which concomitant use is prohibited. One patient was 82 years old and hypertensive; the other was 72 years old and had no cardiovascular risk factors such as hypertension or diabetes mellitus. The arrhythmias were both serious ventricular tachycardia (VT) that converted spontaneously to sinus rhythm, without treatment, and both patients had good outcomes. These cases suggest that LDV/SOF may be associated with an increased risk of heart-related events.
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spelling pubmed-54579212017-06-08 Ventricular Tachycardia as a Complication of Ledipasvir and Sofosbuvir Treatment for HCV Infection Nirei, Kazushige Nakamura, Hitomi Matsuoka, Shunichi Yamana, Yoichiro Yoda, Shunichi Hirayama, Atsushi Moriyama, Mitsuhiko Intern Med Case Report We experienced two patients with serious arrhythmias associated with the administration of ledipasvir (LDV) and sofosbuvir (SOF). Neither patient took amiodarone, an agent for which concomitant use is prohibited. One patient was 82 years old and hypertensive; the other was 72 years old and had no cardiovascular risk factors such as hypertension or diabetes mellitus. The arrhythmias were both serious ventricular tachycardia (VT) that converted spontaneously to sinus rhythm, without treatment, and both patients had good outcomes. These cases suggest that LDV/SOF may be associated with an increased risk of heart-related events. The Japanese Society of Internal Medicine 2017-04-01 /pmc/articles/PMC5457921/ /pubmed/28381744 http://dx.doi.org/10.2169/internalmedicine.56.7948 Text en Copyright © 2017 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Nirei, Kazushige
Nakamura, Hitomi
Matsuoka, Shunichi
Yamana, Yoichiro
Yoda, Shunichi
Hirayama, Atsushi
Moriyama, Mitsuhiko
Ventricular Tachycardia as a Complication of Ledipasvir and Sofosbuvir Treatment for HCV Infection
title Ventricular Tachycardia as a Complication of Ledipasvir and Sofosbuvir Treatment for HCV Infection
title_full Ventricular Tachycardia as a Complication of Ledipasvir and Sofosbuvir Treatment for HCV Infection
title_fullStr Ventricular Tachycardia as a Complication of Ledipasvir and Sofosbuvir Treatment for HCV Infection
title_full_unstemmed Ventricular Tachycardia as a Complication of Ledipasvir and Sofosbuvir Treatment for HCV Infection
title_short Ventricular Tachycardia as a Complication of Ledipasvir and Sofosbuvir Treatment for HCV Infection
title_sort ventricular tachycardia as a complication of ledipasvir and sofosbuvir treatment for hcv infection
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5457921/
https://www.ncbi.nlm.nih.gov/pubmed/28381744
http://dx.doi.org/10.2169/internalmedicine.56.7948
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