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Pulmonary Artery Sarcoma Overexpressing Platelet-derived Growth Factor Receptor α
Pulmonary artery sarcoma is highly malignant and easily metastasizes to the systemic organs. Both the introduction of novel diagnostic procedures and the development of new treatment modalities are required to achieve long-term survival. Several studies have shown that platelet-derived growth factor...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Japanese Society of Internal Medicine
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5457927/ https://www.ncbi.nlm.nih.gov/pubmed/28381750 http://dx.doi.org/10.2169/internalmedicine.56.7731 |
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author | Takemoto, Shinnosuke Soda, Hiroshi Iwasaki, Keisuke Kitazaki, Takeshi Sumiyoshi, Makoto Harada, Tatsuhiko Dotsu, Yosuke Ogawara, Daiki Fukahori, Susumu Fukuda, Yuichi Mukae, Hiroshi |
author_facet | Takemoto, Shinnosuke Soda, Hiroshi Iwasaki, Keisuke Kitazaki, Takeshi Sumiyoshi, Makoto Harada, Tatsuhiko Dotsu, Yosuke Ogawara, Daiki Fukahori, Susumu Fukuda, Yuichi Mukae, Hiroshi |
author_sort | Takemoto, Shinnosuke |
collection | PubMed |
description | Pulmonary artery sarcoma is highly malignant and easily metastasizes to the systemic organs. Both the introduction of novel diagnostic procedures and the development of new treatment modalities are required to achieve long-term survival. Several studies have shown that platelet-derived growth factor receptor α (PDGFRα) gene amplification is frequently observed in pulmonary artery sarcoma. PDGFRα is known to be involved in cell proliferation in certain malignancies. PDGFRα may become a potential biological marker in pulmonary artery sarcoma. We report a case in which a diagnosis of pulmonary artery sarcoma overexpressing PDGFRα was made using endovascular catheter biopsy following positron emission tomography with integrated computed tomography (PET/CT) scans. |
format | Online Article Text |
id | pubmed-5457927 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | The Japanese Society of Internal Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-54579272017-06-08 Pulmonary Artery Sarcoma Overexpressing Platelet-derived Growth Factor Receptor α Takemoto, Shinnosuke Soda, Hiroshi Iwasaki, Keisuke Kitazaki, Takeshi Sumiyoshi, Makoto Harada, Tatsuhiko Dotsu, Yosuke Ogawara, Daiki Fukahori, Susumu Fukuda, Yuichi Mukae, Hiroshi Intern Med Case Report Pulmonary artery sarcoma is highly malignant and easily metastasizes to the systemic organs. Both the introduction of novel diagnostic procedures and the development of new treatment modalities are required to achieve long-term survival. Several studies have shown that platelet-derived growth factor receptor α (PDGFRα) gene amplification is frequently observed in pulmonary artery sarcoma. PDGFRα is known to be involved in cell proliferation in certain malignancies. PDGFRα may become a potential biological marker in pulmonary artery sarcoma. We report a case in which a diagnosis of pulmonary artery sarcoma overexpressing PDGFRα was made using endovascular catheter biopsy following positron emission tomography with integrated computed tomography (PET/CT) scans. The Japanese Society of Internal Medicine 2017-04-01 /pmc/articles/PMC5457927/ /pubmed/28381750 http://dx.doi.org/10.2169/internalmedicine.56.7731 Text en Copyright © 2017 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Case Report Takemoto, Shinnosuke Soda, Hiroshi Iwasaki, Keisuke Kitazaki, Takeshi Sumiyoshi, Makoto Harada, Tatsuhiko Dotsu, Yosuke Ogawara, Daiki Fukahori, Susumu Fukuda, Yuichi Mukae, Hiroshi Pulmonary Artery Sarcoma Overexpressing Platelet-derived Growth Factor Receptor α |
title | Pulmonary Artery Sarcoma Overexpressing Platelet-derived Growth Factor Receptor α |
title_full | Pulmonary Artery Sarcoma Overexpressing Platelet-derived Growth Factor Receptor α |
title_fullStr | Pulmonary Artery Sarcoma Overexpressing Platelet-derived Growth Factor Receptor α |
title_full_unstemmed | Pulmonary Artery Sarcoma Overexpressing Platelet-derived Growth Factor Receptor α |
title_short | Pulmonary Artery Sarcoma Overexpressing Platelet-derived Growth Factor Receptor α |
title_sort | pulmonary artery sarcoma overexpressing platelet-derived growth factor receptor α |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5457927/ https://www.ncbi.nlm.nih.gov/pubmed/28381750 http://dx.doi.org/10.2169/internalmedicine.56.7731 |
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