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Pulmonary Artery Sarcoma Overexpressing Platelet-derived Growth Factor Receptor α

Pulmonary artery sarcoma is highly malignant and easily metastasizes to the systemic organs. Both the introduction of novel diagnostic procedures and the development of new treatment modalities are required to achieve long-term survival. Several studies have shown that platelet-derived growth factor...

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Autores principales: Takemoto, Shinnosuke, Soda, Hiroshi, Iwasaki, Keisuke, Kitazaki, Takeshi, Sumiyoshi, Makoto, Harada, Tatsuhiko, Dotsu, Yosuke, Ogawara, Daiki, Fukahori, Susumu, Fukuda, Yuichi, Mukae, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5457927/
https://www.ncbi.nlm.nih.gov/pubmed/28381750
http://dx.doi.org/10.2169/internalmedicine.56.7731
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author Takemoto, Shinnosuke
Soda, Hiroshi
Iwasaki, Keisuke
Kitazaki, Takeshi
Sumiyoshi, Makoto
Harada, Tatsuhiko
Dotsu, Yosuke
Ogawara, Daiki
Fukahori, Susumu
Fukuda, Yuichi
Mukae, Hiroshi
author_facet Takemoto, Shinnosuke
Soda, Hiroshi
Iwasaki, Keisuke
Kitazaki, Takeshi
Sumiyoshi, Makoto
Harada, Tatsuhiko
Dotsu, Yosuke
Ogawara, Daiki
Fukahori, Susumu
Fukuda, Yuichi
Mukae, Hiroshi
author_sort Takemoto, Shinnosuke
collection PubMed
description Pulmonary artery sarcoma is highly malignant and easily metastasizes to the systemic organs. Both the introduction of novel diagnostic procedures and the development of new treatment modalities are required to achieve long-term survival. Several studies have shown that platelet-derived growth factor receptor α (PDGFRα) gene amplification is frequently observed in pulmonary artery sarcoma. PDGFRα is known to be involved in cell proliferation in certain malignancies. PDGFRα may become a potential biological marker in pulmonary artery sarcoma. We report a case in which a diagnosis of pulmonary artery sarcoma overexpressing PDGFRα was made using endovascular catheter biopsy following positron emission tomography with integrated computed tomography (PET/CT) scans.
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spelling pubmed-54579272017-06-08 Pulmonary Artery Sarcoma Overexpressing Platelet-derived Growth Factor Receptor α Takemoto, Shinnosuke Soda, Hiroshi Iwasaki, Keisuke Kitazaki, Takeshi Sumiyoshi, Makoto Harada, Tatsuhiko Dotsu, Yosuke Ogawara, Daiki Fukahori, Susumu Fukuda, Yuichi Mukae, Hiroshi Intern Med Case Report Pulmonary artery sarcoma is highly malignant and easily metastasizes to the systemic organs. Both the introduction of novel diagnostic procedures and the development of new treatment modalities are required to achieve long-term survival. Several studies have shown that platelet-derived growth factor receptor α (PDGFRα) gene amplification is frequently observed in pulmonary artery sarcoma. PDGFRα is known to be involved in cell proliferation in certain malignancies. PDGFRα may become a potential biological marker in pulmonary artery sarcoma. We report a case in which a diagnosis of pulmonary artery sarcoma overexpressing PDGFRα was made using endovascular catheter biopsy following positron emission tomography with integrated computed tomography (PET/CT) scans. The Japanese Society of Internal Medicine 2017-04-01 /pmc/articles/PMC5457927/ /pubmed/28381750 http://dx.doi.org/10.2169/internalmedicine.56.7731 Text en Copyright © 2017 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Takemoto, Shinnosuke
Soda, Hiroshi
Iwasaki, Keisuke
Kitazaki, Takeshi
Sumiyoshi, Makoto
Harada, Tatsuhiko
Dotsu, Yosuke
Ogawara, Daiki
Fukahori, Susumu
Fukuda, Yuichi
Mukae, Hiroshi
Pulmonary Artery Sarcoma Overexpressing Platelet-derived Growth Factor Receptor α
title Pulmonary Artery Sarcoma Overexpressing Platelet-derived Growth Factor Receptor α
title_full Pulmonary Artery Sarcoma Overexpressing Platelet-derived Growth Factor Receptor α
title_fullStr Pulmonary Artery Sarcoma Overexpressing Platelet-derived Growth Factor Receptor α
title_full_unstemmed Pulmonary Artery Sarcoma Overexpressing Platelet-derived Growth Factor Receptor α
title_short Pulmonary Artery Sarcoma Overexpressing Platelet-derived Growth Factor Receptor α
title_sort pulmonary artery sarcoma overexpressing platelet-derived growth factor receptor α
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5457927/
https://www.ncbi.nlm.nih.gov/pubmed/28381750
http://dx.doi.org/10.2169/internalmedicine.56.7731
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