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NIRF Heptamethine Cyanine Dye Nanocomplexes for Multi Modal Theranosis of Tumors

Heptamethine cyanine dyes are categorized as a class of near infrared fluorescent (NIRF) dyes which have been discovered to have tumor targeting and accumulation capability. This unique feature of NIRF dye makes it a promising candidate for imaging, targeted therapy and also as a drug delivery vehic...

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Autores principales: Thomas, Reju George, Jeong, Yong Yeon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chonnam National University Medical School 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5457956/
https://www.ncbi.nlm.nih.gov/pubmed/28584786
http://dx.doi.org/10.4068/cmj.2017.53.2.83
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author Thomas, Reju George
Jeong, Yong Yeon
author_facet Thomas, Reju George
Jeong, Yong Yeon
author_sort Thomas, Reju George
collection PubMed
description Heptamethine cyanine dyes are categorized as a class of near infrared fluorescent (NIRF) dyes which have been discovered to have tumor targeting and accumulation capability. This unique feature of NIRF dye makes it a promising candidate for imaging, targeted therapy and also as a drug delivery vehicle for various types of cancers. The favored uptake of dyes only in cancer cells is facilitated by several factors which include organic anion-transporting polypeptides, high mitochondrial membrane potential and tumor hypoxia in cancer cells. Currently nanotechnology has opened possibilities for multimodal or multifunctional strategies for cancer treatment. Including heptamethine cyanine dyes in nanoparticle based delivery systems have generally improved its theranostic ability by several fold owing to the multiple functionalities and structural features of heptamethine dyes. For this reason, nanocomplexes with NIRF heptamethine cyanine dye probe are preferred over non-targeting dyes such as indo cyanine green (ICG). This review sums up current trends and progress in NIRF heptamethine cyanine dye, including dye properties, multifunctional imaging and therapeutic applications in cancer.
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spelling pubmed-54579562017-06-05 NIRF Heptamethine Cyanine Dye Nanocomplexes for Multi Modal Theranosis of Tumors Thomas, Reju George Jeong, Yong Yeon Chonnam Med J Review Article Heptamethine cyanine dyes are categorized as a class of near infrared fluorescent (NIRF) dyes which have been discovered to have tumor targeting and accumulation capability. This unique feature of NIRF dye makes it a promising candidate for imaging, targeted therapy and also as a drug delivery vehicle for various types of cancers. The favored uptake of dyes only in cancer cells is facilitated by several factors which include organic anion-transporting polypeptides, high mitochondrial membrane potential and tumor hypoxia in cancer cells. Currently nanotechnology has opened possibilities for multimodal or multifunctional strategies for cancer treatment. Including heptamethine cyanine dyes in nanoparticle based delivery systems have generally improved its theranostic ability by several fold owing to the multiple functionalities and structural features of heptamethine dyes. For this reason, nanocomplexes with NIRF heptamethine cyanine dye probe are preferred over non-targeting dyes such as indo cyanine green (ICG). This review sums up current trends and progress in NIRF heptamethine cyanine dye, including dye properties, multifunctional imaging and therapeutic applications in cancer. Chonnam National University Medical School 2017-05 2017-05-25 /pmc/articles/PMC5457956/ /pubmed/28584786 http://dx.doi.org/10.4068/cmj.2017.53.2.83 Text en © Chonnam Medical Journal, 2017 http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Thomas, Reju George
Jeong, Yong Yeon
NIRF Heptamethine Cyanine Dye Nanocomplexes for Multi Modal Theranosis of Tumors
title NIRF Heptamethine Cyanine Dye Nanocomplexes for Multi Modal Theranosis of Tumors
title_full NIRF Heptamethine Cyanine Dye Nanocomplexes for Multi Modal Theranosis of Tumors
title_fullStr NIRF Heptamethine Cyanine Dye Nanocomplexes for Multi Modal Theranosis of Tumors
title_full_unstemmed NIRF Heptamethine Cyanine Dye Nanocomplexes for Multi Modal Theranosis of Tumors
title_short NIRF Heptamethine Cyanine Dye Nanocomplexes for Multi Modal Theranosis of Tumors
title_sort nirf heptamethine cyanine dye nanocomplexes for multi modal theranosis of tumors
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5457956/
https://www.ncbi.nlm.nih.gov/pubmed/28584786
http://dx.doi.org/10.4068/cmj.2017.53.2.83
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