Design of synthetic epigenetic circuits featuring memory effects and reversible switching based on DNA methylation

Epigenetic systems store information in DNA methylation patterns in a durable but reversible manner, but have not been regularly used in synthetic biology. Here, we designed synthetic epigenetic memory systems using DNA methylation sensitive engineered zinc finger proteins to repress a memory operon...

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Detalles Bibliográficos
Autores principales: Maier, Johannes A. H., Möhrle, Raphael, Jeltsch, Albert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458116/
https://www.ncbi.nlm.nih.gov/pubmed/28537256
http://dx.doi.org/10.1038/ncomms15336

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458116/
https://www.ncbi.nlm.nih.gov/pubmed/28537256
http://dx.doi.org/10.1038/ncomms15336

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