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Design of synthetic epigenetic circuits featuring memory effects and reversible switching based on DNA methylation
Epigenetic systems store information in DNA methylation patterns in a durable but reversible manner, but have not been regularly used in synthetic biology. Here, we designed synthetic epigenetic memory systems using DNA methylation sensitive engineered zinc finger proteins to repress a memory operon...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458116/ https://www.ncbi.nlm.nih.gov/pubmed/28537256 http://dx.doi.org/10.1038/ncomms15336 |