pSILAC mass spectrometry reveals ZFP91 as IMiD-dependent substrate of the CRL4(CRBN) ubiquitin ligase

Thalidomide and its derivatives lenalidomide and pomalidomide (IMiDs) are effective treatments of haematologic malignancies. It was shown that IMiDs impart gain-of-function properties to the CUL4-RBX1-DDB1-CRBN (CRL4(CRBN)) ubiquitin ligase that enable binding, ubiquitination and degradation of key...

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Detalles Bibliográficos
Autores principales: An, Jian, Ponthier, Charles M., Sack, Ragna, Seebacher, Jan, Stadler, Michael B., Donovan, Katherine A., Fischer, Eric S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458144/
https://www.ncbi.nlm.nih.gov/pubmed/28530236
http://dx.doi.org/10.1038/ncomms15398

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