Cargando…

Senoptosis: non-lethal DNA cleavage as a route to deep senescence

DNA-damage-induced apoptosis and cellular senescence are perceived as two distinct cell fates. We found that after ionizing radiation (IR)-induced DNA damage the majority (up to 70 %) of senescent human diploid fibroblasts (HDFs) were subjected to controlled cleavage of DNA, resulting in the establi...

Descripción completa

Detalles Bibliográficos
Autores principales: Studencka, Maja, Schaber, Jörg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458157/
https://www.ncbi.nlm.nih.gov/pubmed/28427150
http://dx.doi.org/10.18632/oncotarget.15693