A highly conserved redox-active Mx((2))CWx((6))R motif regulates Zap70 stability and activity

ζ-associated protein of 70 kDa (Zap70) is crucial for T-cell receptor (TCR) signaling. Loss of Zap70 in both humans and mice results in severe immunodeficiency. On the other hand, the expression of Zap70 in B-cell malignancies correlates with the severity of the disease. Because of its role in immun...

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Detalles Bibliográficos
Autores principales: Thurm, Christoph, Poltorak, Mateusz P., Reimer, Elisa, Brinkmann, Melanie M., Leichert, Lars, Schraven, Burkhart, Simeoni, Luca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper: Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458169/
https://www.ncbi.nlm.nih.gov/pubmed/28415650
http://dx.doi.org/10.18632/oncotarget.16486

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458169/
https://www.ncbi.nlm.nih.gov/pubmed/28415650
http://dx.doi.org/10.18632/oncotarget.16486

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