Cargando…
Ponatinib promotes a G(1) cell-cycle arrest of merlin/NF2-deficient human schwann cells
Neurofibromatosis type 2 (NF2) is a genetic syndrome that predisposes individuals to multiple benign tumors of the central and peripheral nervous systems, including vestibular schwannomas. Currently, there are no FDA approved drug therapies for NF2. Loss of function of merlin encoded by the NF2 tumo...
Autores principales: | Petrilli, Alejandra M, Garcia, Jeanine, Bott, Marga, Plati, Stephani Klingeman, Dinh, Christine T, Bracho, Olena R, Yan, Denise, Zou, Bing, Mittal, Rahul, Telischi, Fred F, Liu, Xue-Zhong, Chang, Long-Sheng, Bradley, D Welling, Copik, Alicja J, Fernández-Valle, Cristina |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458238/ https://www.ncbi.nlm.nih.gov/pubmed/28427224 http://dx.doi.org/10.18632/oncotarget.15912 |
Ejemplares similares
-
Inhibition of SIRT2 in merlin/NF2-mutant Schwann cells triggers necrosis
por: Petrilli, Alejandra M., et al.
Publicado: (2013) -
Peroxynitrite supports a metabolic reprogramming in merlin-deficient Schwann cells and promotes cell survival
por: Pestoni, Jeanine C., et al.
Publicado: (2019) -
Single Fraction and Hypofractionated Radiation Cause Cochlear Damage, Hearing Loss, and Reduced Viability of Merlin-Deficient Schwann Cells
por: Dinh, Christine T., et al.
Publicado: (2023) -
Role of Merlin/NF2 Inactivation in Tumor Biology
por: Petrilli, Alejandra M., et al.
Publicado: (2015) -
Stability of the tumor suppressor merlin depends on its ability to bind paxillin LD3 and associate with β1 integrin and actin at the plasma membrane
por: Manetti, Maria Elisa, et al.
Publicado: (2012)