Cargando…

Elevated FOXO6 expression correlates with progression and prognosis in gastric cancer

The FOXO6 correlated with tumor progression in a wide range of carcinomas, yet little is known in gastric cancer. The expression of FOXO6 and matrix metallopeptidase 9 (MMP-9) was assessed by immunohistochemistry in 192 gastric carcinoma specimens. The correlation between FOXO6 expression with MMP-9...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Jia-Hong, Tang, Hong-sheng, Li, Xiao-Shan, Zhang, Xiang-Liang, Yang, Xian-Zi, Zeng, Li-Si, Ruan, Qiang, Huang, Yong-Hong, Liu, Gao-Jie, Wang, Jin, Cui, Shu-Zhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458239/
https://www.ncbi.nlm.nih.gov/pubmed/28404958
http://dx.doi.org/10.18632/oncotarget.15920
_version_ 1783241719093919744
author Wang, Jia-Hong
Tang, Hong-sheng
Li, Xiao-Shan
Zhang, Xiang-Liang
Yang, Xian-Zi
Zeng, Li-Si
Ruan, Qiang
Huang, Yong-Hong
Liu, Gao-Jie
Wang, Jin
Cui, Shu-Zhong
author_facet Wang, Jia-Hong
Tang, Hong-sheng
Li, Xiao-Shan
Zhang, Xiang-Liang
Yang, Xian-Zi
Zeng, Li-Si
Ruan, Qiang
Huang, Yong-Hong
Liu, Gao-Jie
Wang, Jin
Cui, Shu-Zhong
author_sort Wang, Jia-Hong
collection PubMed
description The FOXO6 correlated with tumor progression in a wide range of carcinomas, yet little is known in gastric cancer. The expression of FOXO6 and matrix metallopeptidase 9 (MMP-9) was assessed by immunohistochemistry in 192 gastric carcinoma specimens. The correlation between FOXO6 expression with MMP-9, clinicopathological/prognostic value in gastric cancer was examined. FOXO6 overexpression was significantly associated with depth of invasion, lymph node metastasis and stage of disease. In univariate and multivariate analyses, FOXO6 was an independent prognostic factor for both overall survival (OS) and recurrence-free survival (RFS). Moreover, FOXO6 over-expression was correlated with poor prognosis in patients subgroups stratified by tumor size, depth of invasion and lymph node metastasis. FOXO6 expression was increased in both prominent serosal invasion group and lymph node metastasis group. In addition, FOXO6 expression was positively correlated with MMP-9 among 192 gastric cancer tissues. Patients with FOXO6 over-expression had poor OS and shorter RFS in low and high invasiveness groups. Furthermore, stratified analysis showed that the TNM stage I patients with high FOXO6 expression had poor prognosis than those with low FOXO6 expression. In conclusion, FOXO6 overexpression promotes tumor aggressiveness and prognosis, and could be a promising target for prognostic prediction in gastric cancer patients. CONDENSED ABSTRACT: The aim of this study was to analyze the role of FOXO6 in patients with gastric carcinoma. FOXO6 may play an important role on tumor invasion, metastasis and prognosis. It may also serve as a novel target for prognostic prediction.
format Online
Article
Text
id pubmed-5458239
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Impact Journals LLC
record_format MEDLINE/PubMed
spelling pubmed-54582392017-06-08 Elevated FOXO6 expression correlates with progression and prognosis in gastric cancer Wang, Jia-Hong Tang, Hong-sheng Li, Xiao-Shan Zhang, Xiang-Liang Yang, Xian-Zi Zeng, Li-Si Ruan, Qiang Huang, Yong-Hong Liu, Gao-Jie Wang, Jin Cui, Shu-Zhong Oncotarget Research Paper The FOXO6 correlated with tumor progression in a wide range of carcinomas, yet little is known in gastric cancer. The expression of FOXO6 and matrix metallopeptidase 9 (MMP-9) was assessed by immunohistochemistry in 192 gastric carcinoma specimens. The correlation between FOXO6 expression with MMP-9, clinicopathological/prognostic value in gastric cancer was examined. FOXO6 overexpression was significantly associated with depth of invasion, lymph node metastasis and stage of disease. In univariate and multivariate analyses, FOXO6 was an independent prognostic factor for both overall survival (OS) and recurrence-free survival (RFS). Moreover, FOXO6 over-expression was correlated with poor prognosis in patients subgroups stratified by tumor size, depth of invasion and lymph node metastasis. FOXO6 expression was increased in both prominent serosal invasion group and lymph node metastasis group. In addition, FOXO6 expression was positively correlated with MMP-9 among 192 gastric cancer tissues. Patients with FOXO6 over-expression had poor OS and shorter RFS in low and high invasiveness groups. Furthermore, stratified analysis showed that the TNM stage I patients with high FOXO6 expression had poor prognosis than those with low FOXO6 expression. In conclusion, FOXO6 overexpression promotes tumor aggressiveness and prognosis, and could be a promising target for prognostic prediction in gastric cancer patients. CONDENSED ABSTRACT: The aim of this study was to analyze the role of FOXO6 in patients with gastric carcinoma. FOXO6 may play an important role on tumor invasion, metastasis and prognosis. It may also serve as a novel target for prognostic prediction. Impact Journals LLC 2017-03-06 /pmc/articles/PMC5458239/ /pubmed/28404958 http://dx.doi.org/10.18632/oncotarget.15920 Text en Copyright: © 2017 Wang et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Wang, Jia-Hong
Tang, Hong-sheng
Li, Xiao-Shan
Zhang, Xiang-Liang
Yang, Xian-Zi
Zeng, Li-Si
Ruan, Qiang
Huang, Yong-Hong
Liu, Gao-Jie
Wang, Jin
Cui, Shu-Zhong
Elevated FOXO6 expression correlates with progression and prognosis in gastric cancer
title Elevated FOXO6 expression correlates with progression and prognosis in gastric cancer
title_full Elevated FOXO6 expression correlates with progression and prognosis in gastric cancer
title_fullStr Elevated FOXO6 expression correlates with progression and prognosis in gastric cancer
title_full_unstemmed Elevated FOXO6 expression correlates with progression and prognosis in gastric cancer
title_short Elevated FOXO6 expression correlates with progression and prognosis in gastric cancer
title_sort elevated foxo6 expression correlates with progression and prognosis in gastric cancer
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458239/
https://www.ncbi.nlm.nih.gov/pubmed/28404958
http://dx.doi.org/10.18632/oncotarget.15920
work_keys_str_mv AT wangjiahong elevatedfoxo6expressioncorrelateswithprogressionandprognosisingastriccancer
AT tanghongsheng elevatedfoxo6expressioncorrelateswithprogressionandprognosisingastriccancer
AT lixiaoshan elevatedfoxo6expressioncorrelateswithprogressionandprognosisingastriccancer
AT zhangxiangliang elevatedfoxo6expressioncorrelateswithprogressionandprognosisingastriccancer
AT yangxianzi elevatedfoxo6expressioncorrelateswithprogressionandprognosisingastriccancer
AT zenglisi elevatedfoxo6expressioncorrelateswithprogressionandprognosisingastriccancer
AT ruanqiang elevatedfoxo6expressioncorrelateswithprogressionandprognosisingastriccancer
AT huangyonghong elevatedfoxo6expressioncorrelateswithprogressionandprognosisingastriccancer
AT liugaojie elevatedfoxo6expressioncorrelateswithprogressionandprognosisingastriccancer
AT wangjin elevatedfoxo6expressioncorrelateswithprogressionandprognosisingastriccancer
AT cuishuzhong elevatedfoxo6expressioncorrelateswithprogressionandprognosisingastriccancer