Anti-helminthic niclosamide inhibits Ras-driven oncogenic transformation via activation of GSK-3

Despite the importance of Ras oncogenes as a therapeutic target in human cancer, their ‘undruggable’ tertiary structures limit the effectiveness of anti-Ras drugs. Canonical Wnt signaling contributes to Ras activity by glycogen synthase kinase 3 (GSK-3)-dependent phosphorylation at the C-terminus an...

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Detalles Bibliográficos
Autores principales: Ahn, Sung Yong, Yang, Ji Hye, Kim, Nam Hee, Lee, Kyungro, Cha, Yong Hoon, Yun, Jun Seop, Kang, Hee Eun, Lee, Yoonmi, Choi, Jiwon, Kim, Hyun Sil, Yook, Jong In
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458253/
https://www.ncbi.nlm.nih.gov/pubmed/28418865
http://dx.doi.org/10.18632/oncotarget.16255

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458253/
https://www.ncbi.nlm.nih.gov/pubmed/28418865
http://dx.doi.org/10.18632/oncotarget.16255

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