Tanshinone II Aattenuates renal damage in STZ-induced diabetic rats via inhibiting oxidative stress and inflammation

Oxidative stress and inflammation have been demonstrated to be involved in the onset and promotion of diabetic nephropathy (DN).Tanshinone IIA (Tan) possesses both antioxidant and anti-inflammatory properties. Here, the aim of the present study was to explore whether Tan could attenuate renal damage...

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Autores principales: Chen, Xia, Wu, Rui, Kong, Yiwei, Yang, Yuting, Gao, Yu, Sun, Dandan, Liu, Qizhen, Dai, Dongjun, Lu, Zeyuan, Wang, Niansong, Ge, Sheng, Wang, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458258/
https://www.ncbi.nlm.nih.gov/pubmed/28404881
http://dx.doi.org/10.18632/oncotarget.16651
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author Chen, Xia
Wu, Rui
Kong, Yiwei
Yang, Yuting
Gao, Yu
Sun, Dandan
Liu, Qizhen
Dai, Dongjun
Lu, Zeyuan
Wang, Niansong
Ge, Sheng
Wang, Feng
author_facet Chen, Xia
Wu, Rui
Kong, Yiwei
Yang, Yuting
Gao, Yu
Sun, Dandan
Liu, Qizhen
Dai, Dongjun
Lu, Zeyuan
Wang, Niansong
Ge, Sheng
Wang, Feng
author_sort Chen, Xia
collection PubMed
description Oxidative stress and inflammation have been demonstrated to be involved in the onset and promotion of diabetic nephropathy (DN).Tanshinone IIA (Tan) possesses both antioxidant and anti-inflammatory properties. Here, the aim of the present study was to explore whether Tan could attenuate renal damage in the rats with streptozotocin (STZ)-induced diabetes and its potential mechanisms. Tan was gavaged to STZ-induced diabetic rats at the dose of 10mg/kg once a day for 12 weeks. Tan treatment significantly attenuated albuminuria and renal histopathology in diabetic rats. Besides, Tan treatment also effectively inhibited oxidative stress and inflammatory reaction in the kidneys of diabetic rats. Our study provided evidence that the protective effect of Tan on diabetes-induced renal injury is associated with inhibition of oxidative stress and inflammation. Tan may be a potential candidate for the treatment of DN.
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spelling pubmed-54582582017-06-08 Tanshinone II Aattenuates renal damage in STZ-induced diabetic rats via inhibiting oxidative stress and inflammation Chen, Xia Wu, Rui Kong, Yiwei Yang, Yuting Gao, Yu Sun, Dandan Liu, Qizhen Dai, Dongjun Lu, Zeyuan Wang, Niansong Ge, Sheng Wang, Feng Oncotarget Research Paper Oxidative stress and inflammation have been demonstrated to be involved in the onset and promotion of diabetic nephropathy (DN).Tanshinone IIA (Tan) possesses both antioxidant and anti-inflammatory properties. Here, the aim of the present study was to explore whether Tan could attenuate renal damage in the rats with streptozotocin (STZ)-induced diabetes and its potential mechanisms. Tan was gavaged to STZ-induced diabetic rats at the dose of 10mg/kg once a day for 12 weeks. Tan treatment significantly attenuated albuminuria and renal histopathology in diabetic rats. Besides, Tan treatment also effectively inhibited oxidative stress and inflammatory reaction in the kidneys of diabetic rats. Our study provided evidence that the protective effect of Tan on diabetes-induced renal injury is associated with inhibition of oxidative stress and inflammation. Tan may be a potential candidate for the treatment of DN. Impact Journals LLC 2017-03-29 /pmc/articles/PMC5458258/ /pubmed/28404881 http://dx.doi.org/10.18632/oncotarget.16651 Text en Copyright: © 2017 Chen et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Chen, Xia
Wu, Rui
Kong, Yiwei
Yang, Yuting
Gao, Yu
Sun, Dandan
Liu, Qizhen
Dai, Dongjun
Lu, Zeyuan
Wang, Niansong
Ge, Sheng
Wang, Feng
Tanshinone II Aattenuates renal damage in STZ-induced diabetic rats via inhibiting oxidative stress and inflammation
title Tanshinone II Aattenuates renal damage in STZ-induced diabetic rats via inhibiting oxidative stress and inflammation
title_full Tanshinone II Aattenuates renal damage in STZ-induced diabetic rats via inhibiting oxidative stress and inflammation
title_fullStr Tanshinone II Aattenuates renal damage in STZ-induced diabetic rats via inhibiting oxidative stress and inflammation
title_full_unstemmed Tanshinone II Aattenuates renal damage in STZ-induced diabetic rats via inhibiting oxidative stress and inflammation
title_short Tanshinone II Aattenuates renal damage in STZ-induced diabetic rats via inhibiting oxidative stress and inflammation
title_sort tanshinone ii aattenuates renal damage in stz-induced diabetic rats via inhibiting oxidative stress and inflammation
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458258/
https://www.ncbi.nlm.nih.gov/pubmed/28404881
http://dx.doi.org/10.18632/oncotarget.16651
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