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Gastrodin protects against LPS-induced acute lung injury by activating Nrf2 signaling pathway
Gastrodin (GAS), a phenolic glucoside derived from Gastrodiaelata Blume, has been reported to have anti-inflammatory effect. The aim of this study was to investigate the effects of GAS on LPS-induced acute lung injury in mice. ALI was induced by the intranasal administration of LPS and GAS was given...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458274/ https://www.ncbi.nlm.nih.gov/pubmed/28389632 http://dx.doi.org/10.18632/oncotarget.16740 |
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author | Zhang, Zhuo Zhou, Jie Song, Daqiang Sun, Yuhong Liao, Changli Jiang, Xian |
author_facet | Zhang, Zhuo Zhou, Jie Song, Daqiang Sun, Yuhong Liao, Changli Jiang, Xian |
author_sort | Zhang, Zhuo |
collection | PubMed |
description | Gastrodin (GAS), a phenolic glucoside derived from Gastrodiaelata Blume, has been reported to have anti-inflammatory effect. The aim of this study was to investigate the effects of GAS on LPS-induced acute lung injury in mice. ALI was induced by the intranasal administration of LPS and GAS was given 1 h or 12 h after LPS treatment. The results indicated that GAS treatment markedly attenuated the damage of lung injury induced by LPS. GAS attenuated the activity of myeloperoxidase (MPO) and down-regulated the levels of pro-inflammatory cytokines TNF-α, IL-6 and IL-1β in BALF. LPS-induced lung edema and lung function were also reversed by GAS. Furthermore, GAS was found to inhibit LPS-induced inflammatory cells infiltration. In addition, treatment of GAS inhibited LPS-induced NF-κB activation and up-regulated the expression of Nrf2 and HO-1. In conclusion, our results indicated that GAS had anti-inflammatory effects on LPS-induced acute lung injury. The anti-inflammatory mechanism of GAS was through the inhibition of NF-κB and activation of Nrf2 signaling pathways. |
format | Online Article Text |
id | pubmed-5458274 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-54582742017-06-08 Gastrodin protects against LPS-induced acute lung injury by activating Nrf2 signaling pathway Zhang, Zhuo Zhou, Jie Song, Daqiang Sun, Yuhong Liao, Changli Jiang, Xian Oncotarget Research Paper Gastrodin (GAS), a phenolic glucoside derived from Gastrodiaelata Blume, has been reported to have anti-inflammatory effect. The aim of this study was to investigate the effects of GAS on LPS-induced acute lung injury in mice. ALI was induced by the intranasal administration of LPS and GAS was given 1 h or 12 h after LPS treatment. The results indicated that GAS treatment markedly attenuated the damage of lung injury induced by LPS. GAS attenuated the activity of myeloperoxidase (MPO) and down-regulated the levels of pro-inflammatory cytokines TNF-α, IL-6 and IL-1β in BALF. LPS-induced lung edema and lung function were also reversed by GAS. Furthermore, GAS was found to inhibit LPS-induced inflammatory cells infiltration. In addition, treatment of GAS inhibited LPS-induced NF-κB activation and up-regulated the expression of Nrf2 and HO-1. In conclusion, our results indicated that GAS had anti-inflammatory effects on LPS-induced acute lung injury. The anti-inflammatory mechanism of GAS was through the inhibition of NF-κB and activation of Nrf2 signaling pathways. Impact Journals LLC 2017-03-31 /pmc/articles/PMC5458274/ /pubmed/28389632 http://dx.doi.org/10.18632/oncotarget.16740 Text en Copyright: © 2017 Zhang et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Zhang, Zhuo Zhou, Jie Song, Daqiang Sun, Yuhong Liao, Changli Jiang, Xian Gastrodin protects against LPS-induced acute lung injury by activating Nrf2 signaling pathway |
title | Gastrodin protects against LPS-induced acute lung injury by activating Nrf2 signaling pathway |
title_full | Gastrodin protects against LPS-induced acute lung injury by activating Nrf2 signaling pathway |
title_fullStr | Gastrodin protects against LPS-induced acute lung injury by activating Nrf2 signaling pathway |
title_full_unstemmed | Gastrodin protects against LPS-induced acute lung injury by activating Nrf2 signaling pathway |
title_short | Gastrodin protects against LPS-induced acute lung injury by activating Nrf2 signaling pathway |
title_sort | gastrodin protects against lps-induced acute lung injury by activating nrf2 signaling pathway |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458274/ https://www.ncbi.nlm.nih.gov/pubmed/28389632 http://dx.doi.org/10.18632/oncotarget.16740 |
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