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Beyond cell-cell adhesion: Plakoglobin and the regulation of tumorigenesis and metastasis
Plakoglobin (also known as? -catenin) is a member of the Armadillo family of proteins and a paralog of β -catenin. Plakoglobin is a component of both the adherens junctions and desmosomes, and therefore plays a vital role in the regulation of cell-cell adhesion. Similar to β -catenin, plakoglobin is...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458283/ https://www.ncbi.nlm.nih.gov/pubmed/28416759 http://dx.doi.org/10.18632/oncotarget.15650 |
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author | Aktary, Zackie Alaee, Mahsa Pasdar, Manijeh |
author_facet | Aktary, Zackie Alaee, Mahsa Pasdar, Manijeh |
author_sort | Aktary, Zackie |
collection | PubMed |
description | Plakoglobin (also known as? -catenin) is a member of the Armadillo family of proteins and a paralog of β -catenin. Plakoglobin is a component of both the adherens junctions and desmosomes, and therefore plays a vital role in the regulation of cell-cell adhesion. Similar to β -catenin, plakoglobin is capable of participating in cell signaling in addition to its role in cell-cell adhesion. In this context, β -catenin has a well-documented oncogenic potential as a component of the Wnt signaling pathway. In contrast, while some studies have suggested a tumor promoting activity of plakoglobin in a cell/malignancy specific context, it generally acts as a tumor/metastasis suppressor. How plakoglobin acts as a growth/metastasis inhibitory protein has remained, until recently, unclear. Recent evidence suggests that plakoglobin may suppress tumorigenesis and metastasis by multiple mechanisms, including the suppression of oncogenic signaling, interactions with various proteins involved in tumorigenesis and metastasis, and the regulation of the expression of genes involved in these processes. This review is primarily focused on various mechanisms by which plakoglobin may inhibit tumorigenesis and metastasis. |
format | Online Article Text |
id | pubmed-5458283 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-54582832017-06-08 Beyond cell-cell adhesion: Plakoglobin and the regulation of tumorigenesis and metastasis Aktary, Zackie Alaee, Mahsa Pasdar, Manijeh Oncotarget Review Plakoglobin (also known as? -catenin) is a member of the Armadillo family of proteins and a paralog of β -catenin. Plakoglobin is a component of both the adherens junctions and desmosomes, and therefore plays a vital role in the regulation of cell-cell adhesion. Similar to β -catenin, plakoglobin is capable of participating in cell signaling in addition to its role in cell-cell adhesion. In this context, β -catenin has a well-documented oncogenic potential as a component of the Wnt signaling pathway. In contrast, while some studies have suggested a tumor promoting activity of plakoglobin in a cell/malignancy specific context, it generally acts as a tumor/metastasis suppressor. How plakoglobin acts as a growth/metastasis inhibitory protein has remained, until recently, unclear. Recent evidence suggests that plakoglobin may suppress tumorigenesis and metastasis by multiple mechanisms, including the suppression of oncogenic signaling, interactions with various proteins involved in tumorigenesis and metastasis, and the regulation of the expression of genes involved in these processes. This review is primarily focused on various mechanisms by which plakoglobin may inhibit tumorigenesis and metastasis. Impact Journals LLC 2017-02-23 /pmc/articles/PMC5458283/ /pubmed/28416759 http://dx.doi.org/10.18632/oncotarget.15650 Text en Copyright: © 2017 Aktary et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Review Aktary, Zackie Alaee, Mahsa Pasdar, Manijeh Beyond cell-cell adhesion: Plakoglobin and the regulation of tumorigenesis and metastasis |
title | Beyond cell-cell adhesion: Plakoglobin and the regulation of tumorigenesis and metastasis |
title_full | Beyond cell-cell adhesion: Plakoglobin and the regulation of tumorigenesis and metastasis |
title_fullStr | Beyond cell-cell adhesion: Plakoglobin and the regulation of tumorigenesis and metastasis |
title_full_unstemmed | Beyond cell-cell adhesion: Plakoglobin and the regulation of tumorigenesis and metastasis |
title_short | Beyond cell-cell adhesion: Plakoglobin and the regulation of tumorigenesis and metastasis |
title_sort | beyond cell-cell adhesion: plakoglobin and the regulation of tumorigenesis and metastasis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458283/ https://www.ncbi.nlm.nih.gov/pubmed/28416759 http://dx.doi.org/10.18632/oncotarget.15650 |
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