Different intra- and inter­molecular hydrogen-bonding patterns in (3S,4aS,8aS)-2-[(2R,3S)-3-(2,5-X (2)-benzamido)-2-(2,5-X (2)-benzo­yloxy)-4-phenyl­butyl]-N-tert-butyldeca­hydro­iso­quinoline-3-carboxamides (X = H or Cl): compounds with moderate aspartyl protease inhibition activity

The crystal structures of (3S,4aS,8aS)-2-[(2R,3S)-3-benzamido-2-benzo­yloxy-4-phenyl­but­yl]-N-tert-butyldeca­hydro­iso­quinoline-3-carboxamide, C(38)H(47)N(3)O(4), (I), and (3S,4aS,8aS)-2-[(2R,3S)-3-(2,5-di­chloro­benzamido)-2-(2,5-di­chloro­benzo­yloxy)-4-phenyl­but­yl]-N-tert-butyldeca­hydro­iso­...

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Detalles Bibliográficos
Autores principales: Cunico, Wilson, Ferreira, Maria de Lourdes G., Wardell, James L., Harrison, William T. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2017
Materias:
Research Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458323/
https://www.ncbi.nlm.nih.gov/pubmed/28638658
http://dx.doi.org/10.1107/S2056989017007800

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