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Chronic Kidney Dysfunction Can Increase the Risk of Deep Vein Thrombosis after Total Hip and Knee Arthroplasty

BACKGROUND: Deep vein thrombosis (DVT) is one of the major complications of total joint arthroplasty (TJA). Chronic kidney dysfunction (CKD) has proven to promote a proinflammatory and prothrombotic state and is prevalent among patients undergoing TJA. The purpose of this study is to identify whethe...

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Autores principales: Li, Qiangqiang, Dai, Bingyang, Yao, Yao, Song, Kai, Chen, Dongyang, Jiang, Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458429/
https://www.ncbi.nlm.nih.gov/pubmed/28612028
http://dx.doi.org/10.1155/2017/8260487
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author Li, Qiangqiang
Dai, Bingyang
Yao, Yao
Song, Kai
Chen, Dongyang
Jiang, Qing
author_facet Li, Qiangqiang
Dai, Bingyang
Yao, Yao
Song, Kai
Chen, Dongyang
Jiang, Qing
author_sort Li, Qiangqiang
collection PubMed
description BACKGROUND: Deep vein thrombosis (DVT) is one of the major complications of total joint arthroplasty (TJA). Chronic kidney dysfunction (CKD) has proven to promote a proinflammatory and prothrombotic state and is prevalent among patients undergoing TJA. The purpose of this study is to identify whether CKD increase the risk of DVT following TJA. METHODS: In a retrospective study, 1274 patients who underwent primary TJA were studied. CKD is graded in 5 stages. Univariate and multivariate analysis were used to identify the association of CKD and its severity with postoperative DVT. RESULTS: There were 1139 (89.4%) participants with normal kidney function, 103 (8.1%) with mildly decreased kidney function, and 32 (2.5%) with stage 3 and 4 CKD. A total of 244 patients (19.2%) were diagnosed with DVT. Sixty-four patients (5.0%) developed symptomatic DVT. Advanced age, female gender, malignancy, and eGFR showed significant association with total DVT. BMI, thrombosis history, malignancy, and eGFR were associated with symptomatic DVT. After adjusting for age, gender, BMI, and malignancy, eGFR was found to be related to both total and symptomatic DVT. CONCLUSIONS: CKD is an important risk factor for both total and symptomatic DVT following TJA. Postoperative prophylaxis should be made a priority in this population.
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spelling pubmed-54584292017-06-13 Chronic Kidney Dysfunction Can Increase the Risk of Deep Vein Thrombosis after Total Hip and Knee Arthroplasty Li, Qiangqiang Dai, Bingyang Yao, Yao Song, Kai Chen, Dongyang Jiang, Qing Biomed Res Int Clinical Study BACKGROUND: Deep vein thrombosis (DVT) is one of the major complications of total joint arthroplasty (TJA). Chronic kidney dysfunction (CKD) has proven to promote a proinflammatory and prothrombotic state and is prevalent among patients undergoing TJA. The purpose of this study is to identify whether CKD increase the risk of DVT following TJA. METHODS: In a retrospective study, 1274 patients who underwent primary TJA were studied. CKD is graded in 5 stages. Univariate and multivariate analysis were used to identify the association of CKD and its severity with postoperative DVT. RESULTS: There were 1139 (89.4%) participants with normal kidney function, 103 (8.1%) with mildly decreased kidney function, and 32 (2.5%) with stage 3 and 4 CKD. A total of 244 patients (19.2%) were diagnosed with DVT. Sixty-four patients (5.0%) developed symptomatic DVT. Advanced age, female gender, malignancy, and eGFR showed significant association with total DVT. BMI, thrombosis history, malignancy, and eGFR were associated with symptomatic DVT. After adjusting for age, gender, BMI, and malignancy, eGFR was found to be related to both total and symptomatic DVT. CONCLUSIONS: CKD is an important risk factor for both total and symptomatic DVT following TJA. Postoperative prophylaxis should be made a priority in this population. Hindawi 2017 2017-05-22 /pmc/articles/PMC5458429/ /pubmed/28612028 http://dx.doi.org/10.1155/2017/8260487 Text en Copyright © 2017 Qiangqiang Li et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Li, Qiangqiang
Dai, Bingyang
Yao, Yao
Song, Kai
Chen, Dongyang
Jiang, Qing
Chronic Kidney Dysfunction Can Increase the Risk of Deep Vein Thrombosis after Total Hip and Knee Arthroplasty
title Chronic Kidney Dysfunction Can Increase the Risk of Deep Vein Thrombosis after Total Hip and Knee Arthroplasty
title_full Chronic Kidney Dysfunction Can Increase the Risk of Deep Vein Thrombosis after Total Hip and Knee Arthroplasty
title_fullStr Chronic Kidney Dysfunction Can Increase the Risk of Deep Vein Thrombosis after Total Hip and Knee Arthroplasty
title_full_unstemmed Chronic Kidney Dysfunction Can Increase the Risk of Deep Vein Thrombosis after Total Hip and Knee Arthroplasty
title_short Chronic Kidney Dysfunction Can Increase the Risk of Deep Vein Thrombosis after Total Hip and Knee Arthroplasty
title_sort chronic kidney dysfunction can increase the risk of deep vein thrombosis after total hip and knee arthroplasty
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458429/
https://www.ncbi.nlm.nih.gov/pubmed/28612028
http://dx.doi.org/10.1155/2017/8260487
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