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Frequency of uterine sarcomas in patients admitted for uterine fibroid surgery

OBJECTIVE: To estimate the frequency of unsuspected uterine sarcoma identified postoperatively in women undergoing surgery for presumed benign uterine fibroids at a single university hospital. MATERIAL AND METHODS: This was a retrospective single-center study; the records of all 2275 patients with u...

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Autores principales: Mettler, Liselotte, Maass, Nicolai, Abdusattarova, Khulkar, Dempfle, Astrid, Alkatout, Ibrahim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Galenos Publishing 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458437/
https://www.ncbi.nlm.nih.gov/pubmed/28400352
http://dx.doi.org/10.4274/jtgga.2016.0248
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author Mettler, Liselotte
Maass, Nicolai
Abdusattarova, Khulkar
Dempfle, Astrid
Alkatout, Ibrahim
author_facet Mettler, Liselotte
Maass, Nicolai
Abdusattarova, Khulkar
Dempfle, Astrid
Alkatout, Ibrahim
author_sort Mettler, Liselotte
collection PubMed
description OBJECTIVE: To estimate the frequency of unsuspected uterine sarcoma identified postoperatively in women undergoing surgery for presumed benign uterine fibroids at a single university hospital. MATERIAL AND METHODS: This was a retrospective single-center study; the records of all 2275 patients with uterine fibroids and uterine sarcomas from 2003 to 2015 were reviewed. Descriptive statistics were used to analyze demographic and clinical characteristics. To calculate confidence intervals (CIs), the Clopper-Pearson Exact method was applied. RESULTS: Preoperatively, 2269 patients had presumed benign uterine fibroids, and six patients had suspected uterine sarcoma. Among the 2269 patients who underwent surgery for presumed uterine fibroids, endometrial stromal sarcoma was histopathologically revealed in only one patient [0.044%, 95% CI: (0.001-0.25)] after laparoscopic subtotal hysterectomy with morcellation. All six patients who were preoperatively diagnosed having uterine sarcoma underwent direct conventional cancer treatment. Histopathologic analyses confirmed four cases of uterine leiomyosarcoma, one high-grade undifferentiated uterine sarcoma, and one embryonal rhabdomyosarcoma. Altogether, seven women were diagnosed as having uterine sarcomas over this twelve-year period. CONCLUSION: In our institution, the frequency of unsuspected uterine sarcomas was 1/2269 (0.044%) among women who underwent myomectomies and hysterectomies to treat presumed benign uterine fibroids.
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spelling pubmed-54584372017-06-13 Frequency of uterine sarcomas in patients admitted for uterine fibroid surgery Mettler, Liselotte Maass, Nicolai Abdusattarova, Khulkar Dempfle, Astrid Alkatout, Ibrahim J Turk Ger Gynecol Assoc Original Investigation OBJECTIVE: To estimate the frequency of unsuspected uterine sarcoma identified postoperatively in women undergoing surgery for presumed benign uterine fibroids at a single university hospital. MATERIAL AND METHODS: This was a retrospective single-center study; the records of all 2275 patients with uterine fibroids and uterine sarcomas from 2003 to 2015 were reviewed. Descriptive statistics were used to analyze demographic and clinical characteristics. To calculate confidence intervals (CIs), the Clopper-Pearson Exact method was applied. RESULTS: Preoperatively, 2269 patients had presumed benign uterine fibroids, and six patients had suspected uterine sarcoma. Among the 2269 patients who underwent surgery for presumed uterine fibroids, endometrial stromal sarcoma was histopathologically revealed in only one patient [0.044%, 95% CI: (0.001-0.25)] after laparoscopic subtotal hysterectomy with morcellation. All six patients who were preoperatively diagnosed having uterine sarcoma underwent direct conventional cancer treatment. Histopathologic analyses confirmed four cases of uterine leiomyosarcoma, one high-grade undifferentiated uterine sarcoma, and one embryonal rhabdomyosarcoma. Altogether, seven women were diagnosed as having uterine sarcomas over this twelve-year period. CONCLUSION: In our institution, the frequency of unsuspected uterine sarcomas was 1/2269 (0.044%) among women who underwent myomectomies and hysterectomies to treat presumed benign uterine fibroids. Galenos Publishing 2017-06 2017-06-01 /pmc/articles/PMC5458437/ /pubmed/28400352 http://dx.doi.org/10.4274/jtgga.2016.0248 Text en ©Copyright 2017 by the Turkish-German Gynecological Education and Research Foundation http://creativecommons.org/licenses/by/2.5/ Journal of the Turkish-German Gynecological Association publishing by Galenos Publishing House.
spellingShingle Original Investigation
Mettler, Liselotte
Maass, Nicolai
Abdusattarova, Khulkar
Dempfle, Astrid
Alkatout, Ibrahim
Frequency of uterine sarcomas in patients admitted for uterine fibroid surgery
title Frequency of uterine sarcomas in patients admitted for uterine fibroid surgery
title_full Frequency of uterine sarcomas in patients admitted for uterine fibroid surgery
title_fullStr Frequency of uterine sarcomas in patients admitted for uterine fibroid surgery
title_full_unstemmed Frequency of uterine sarcomas in patients admitted for uterine fibroid surgery
title_short Frequency of uterine sarcomas in patients admitted for uterine fibroid surgery
title_sort frequency of uterine sarcomas in patients admitted for uterine fibroid surgery
topic Original Investigation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458437/
https://www.ncbi.nlm.nih.gov/pubmed/28400352
http://dx.doi.org/10.4274/jtgga.2016.0248
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