Long-range allosteric regulation of the human 26S proteasome by 20S proteasome-targeting cancer drugs

The proteasome holoenzyme is the major non-lysosomal protease; its proteolytic activity is essential for cellular homeostasis. Thus, it is an attractive target for the development of chemotherapeutics. While the structural basis of core particle (CP) inhibitors is largely understood, their structura...

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Detalles Bibliográficos
Autores principales: Haselbach, David, Schrader, Jil, Lambrecht, Felix, Henneberg, Fabian, Chari, Ashwin, Stark, Holger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458511/
https://www.ncbi.nlm.nih.gov/pubmed/28541292
http://dx.doi.org/10.1038/ncomms15578

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458511/
https://www.ncbi.nlm.nih.gov/pubmed/28541292
http://dx.doi.org/10.1038/ncomms15578

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