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Synthesis of spiro quasi[1]catenanes and quasi[1]rotaxanes via a templated backfolding strategy

Due to their well-defined three-dimensional geometry, spiro compounds are widely utilized in drug research. From the central tetrahedral carbon atom, besides the regular structure, an inverted spiro connectivity may be envisioned. Here we disclose the synthesis of this molecule class that we have co...

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Detalles Bibliográficos
Autores principales: Steemers, Luuk, Wanner, Martin J., Lutz, Martin, Hiemstra, Henk, van Maarseveen, Jan H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458513/
https://www.ncbi.nlm.nih.gov/pubmed/28541349
http://dx.doi.org/10.1038/ncomms15392