Replicating viral vector platform exploits alarmin signals for potent CD8(+) T cell-mediated tumour immunotherapy

Viral infections lead to alarmin release and elicit potent cytotoxic effector T lymphocyte (CTL(eff)) responses. Conversely, the induction of protective tumour-specific CTL(eff) and their recruitment into the tumour remain challenging tasks. Here we show that lymphocytic choriomeningitis virus (LCMV...

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Detalles Bibliográficos
Autores principales: Kallert, Sandra M., Darbre, Stephanie, Bonilla, Weldy V., Kreutzfeldt, Mario, Page, Nicolas, Müller, Philipp, Kreuzaler, Matthias, Lu, Min, Favre, Stéphanie, Kreppel, Florian, Löhning, Max, Luther, Sanjiv A., Zippelius, Alfred, Merkler, Doron, Pinschewer, Daniel D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458557/
https://www.ncbi.nlm.nih.gov/pubmed/28548102
http://dx.doi.org/10.1038/ncomms15327

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