Cargando…

Variables to Predict Nephrological Disease in General, and Glomerulonephritis in Particular, in Patients With Microhematuria

BACKGROUND: Microhematuria (MH) is a symptom frequently leading to uncertainty as to when a nephrology referral is appropriate. Because MH may be indicative of severe kidney disorders, prompt diagnosis and potential treatment initiation can be important. We aimed to identify further variables that p...

Descripción completa

Detalles Bibliográficos
Autores principales: Bramlage, Carsten Paul, Wallbach, Manuel, Ellenberger, David, Deutsch, Cornelia, Minguet, Joan, Smith, Katherine Helen, Stock, Johanna, Goninski, Alina, Bramlage, Peter, Koziolek, Michael, Mueller, Gerhard Anton
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elmer Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458652/
https://www.ncbi.nlm.nih.gov/pubmed/28611855
http://dx.doi.org/10.14740/jocmr2993w
_version_ 1783241800145698816
author Bramlage, Carsten Paul
Wallbach, Manuel
Ellenberger, David
Deutsch, Cornelia
Minguet, Joan
Smith, Katherine Helen
Stock, Johanna
Goninski, Alina
Bramlage, Peter
Koziolek, Michael
Mueller, Gerhard Anton
author_facet Bramlage, Carsten Paul
Wallbach, Manuel
Ellenberger, David
Deutsch, Cornelia
Minguet, Joan
Smith, Katherine Helen
Stock, Johanna
Goninski, Alina
Bramlage, Peter
Koziolek, Michael
Mueller, Gerhard Anton
author_sort Bramlage, Carsten Paul
collection PubMed
description BACKGROUND: Microhematuria (MH) is a symptom frequently leading to uncertainty as to when a nephrology referral is appropriate. Because MH may be indicative of severe kidney disorders, prompt diagnosis and potential treatment initiation can be important. We aimed to identify further variables that point at a nephrological cause, in particular of glomerulonephritis (GN), when MH is diagnosed. METHODS: A retrospective analysis of data acquired from patients attending a nephrology office due to MH was performed. Demographic information and diagnostic tests were evaluated in order to identify factors that were associated with a nephrological cause. RESULTS: Patients with MH (n = 805) as indicated by a urine stick analysis were included. Of these, MH was confirmed by urine sediment analysis in 543 patients (67.5%). Of those, 48.3% had a nephrological cause, including 12.4% with GN and 2.9% with rapid progressive GN (RPGN). A urine dipstick finding of ≥ 250 erythrocytes per microliter, microalbuminuria and elevated leukocytes increased the probability of having a GN to 62.4%. Furthermore, the presence of microalbuminuria, GFR < 60 mL/min, history of hypertension and diabetes mellitus increased the probability for all nephrological causes to 95.4%. CONCLUSION: There are a number of factors available that help to assess the need for a nephrology referral in patients with microhematuria.
format Online
Article
Text
id pubmed-5458652
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Elmer Press
record_format MEDLINE/PubMed
spelling pubmed-54586522017-06-13 Variables to Predict Nephrological Disease in General, and Glomerulonephritis in Particular, in Patients With Microhematuria Bramlage, Carsten Paul Wallbach, Manuel Ellenberger, David Deutsch, Cornelia Minguet, Joan Smith, Katherine Helen Stock, Johanna Goninski, Alina Bramlage, Peter Koziolek, Michael Mueller, Gerhard Anton J Clin Med Res Original Article BACKGROUND: Microhematuria (MH) is a symptom frequently leading to uncertainty as to when a nephrology referral is appropriate. Because MH may be indicative of severe kidney disorders, prompt diagnosis and potential treatment initiation can be important. We aimed to identify further variables that point at a nephrological cause, in particular of glomerulonephritis (GN), when MH is diagnosed. METHODS: A retrospective analysis of data acquired from patients attending a nephrology office due to MH was performed. Demographic information and diagnostic tests were evaluated in order to identify factors that were associated with a nephrological cause. RESULTS: Patients with MH (n = 805) as indicated by a urine stick analysis were included. Of these, MH was confirmed by urine sediment analysis in 543 patients (67.5%). Of those, 48.3% had a nephrological cause, including 12.4% with GN and 2.9% with rapid progressive GN (RPGN). A urine dipstick finding of ≥ 250 erythrocytes per microliter, microalbuminuria and elevated leukocytes increased the probability of having a GN to 62.4%. Furthermore, the presence of microalbuminuria, GFR < 60 mL/min, history of hypertension and diabetes mellitus increased the probability for all nephrological causes to 95.4%. CONCLUSION: There are a number of factors available that help to assess the need for a nephrology referral in patients with microhematuria. Elmer Press 2017-07 2017-05-22 /pmc/articles/PMC5458652/ /pubmed/28611855 http://dx.doi.org/10.14740/jocmr2993w Text en Copyright 2017, Bramlage et al. http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Non-Commercial 4.0 International License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Bramlage, Carsten Paul
Wallbach, Manuel
Ellenberger, David
Deutsch, Cornelia
Minguet, Joan
Smith, Katherine Helen
Stock, Johanna
Goninski, Alina
Bramlage, Peter
Koziolek, Michael
Mueller, Gerhard Anton
Variables to Predict Nephrological Disease in General, and Glomerulonephritis in Particular, in Patients With Microhematuria
title Variables to Predict Nephrological Disease in General, and Glomerulonephritis in Particular, in Patients With Microhematuria
title_full Variables to Predict Nephrological Disease in General, and Glomerulonephritis in Particular, in Patients With Microhematuria
title_fullStr Variables to Predict Nephrological Disease in General, and Glomerulonephritis in Particular, in Patients With Microhematuria
title_full_unstemmed Variables to Predict Nephrological Disease in General, and Glomerulonephritis in Particular, in Patients With Microhematuria
title_short Variables to Predict Nephrological Disease in General, and Glomerulonephritis in Particular, in Patients With Microhematuria
title_sort variables to predict nephrological disease in general, and glomerulonephritis in particular, in patients with microhematuria
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458652/
https://www.ncbi.nlm.nih.gov/pubmed/28611855
http://dx.doi.org/10.14740/jocmr2993w
work_keys_str_mv AT bramlagecarstenpaul variablestopredictnephrologicaldiseaseingeneralandglomerulonephritisinparticularinpatientswithmicrohematuria
AT wallbachmanuel variablestopredictnephrologicaldiseaseingeneralandglomerulonephritisinparticularinpatientswithmicrohematuria
AT ellenbergerdavid variablestopredictnephrologicaldiseaseingeneralandglomerulonephritisinparticularinpatientswithmicrohematuria
AT deutschcornelia variablestopredictnephrologicaldiseaseingeneralandglomerulonephritisinparticularinpatientswithmicrohematuria
AT minguetjoan variablestopredictnephrologicaldiseaseingeneralandglomerulonephritisinparticularinpatientswithmicrohematuria
AT smithkatherinehelen variablestopredictnephrologicaldiseaseingeneralandglomerulonephritisinparticularinpatientswithmicrohematuria
AT stockjohanna variablestopredictnephrologicaldiseaseingeneralandglomerulonephritisinparticularinpatientswithmicrohematuria
AT goninskialina variablestopredictnephrologicaldiseaseingeneralandglomerulonephritisinparticularinpatientswithmicrohematuria
AT bramlagepeter variablestopredictnephrologicaldiseaseingeneralandglomerulonephritisinparticularinpatientswithmicrohematuria
AT koziolekmichael variablestopredictnephrologicaldiseaseingeneralandglomerulonephritisinparticularinpatientswithmicrohematuria
AT muellergerhardanton variablestopredictnephrologicaldiseaseingeneralandglomerulonephritisinparticularinpatientswithmicrohematuria