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Secondary Ammonium Agonists Make Dual Cation-π Interactions in α4β2 Nicotinic Receptors

A cation-π interaction between the ammonium group of an agonist and a conserved tryptophan termed TrpB is a near universal feature of agonist binding to nicotinic acetylcholine receptors (nAChRs). TrpB is one of five residues that form the aromatic box of the agonist binding site, and for the protot...

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Detalles Bibliográficos
Autores principales:	Post, Michael R., Tender, Gabrielle S., Lester, Henry A., Dougherty, Dennis A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Society for Neuroscience 2017
Materias:	New Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458768/ https://www.ncbi.nlm.nih.gov/pubmed/28589175 http://dx.doi.org/10.1523/ENEURO.0032-17.2017

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