Synthesis of Biocompatible Hydroxyapatite Using Chitosan Oligosaccharide as a Template

In this study, a novel biocompatible hydroxyapatite (HA) was synthesized by using chitosan oligosaccharide (COS) as a template. These HA samples were studied by Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), and transmission electron...

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Autores principales: Wang, Jinyu, Liu, Guanxiong, Chen, Jinshuai, Zhao, Bo, Zhu, Peizhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458867/
https://www.ncbi.nlm.nih.gov/pubmed/28793700
http://dx.doi.org/10.3390/ma8125440
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author Wang, Jinyu
Liu, Guanxiong
Chen, Jinshuai
Zhao, Bo
Zhu, Peizhi
author_facet Wang, Jinyu
Liu, Guanxiong
Chen, Jinshuai
Zhao, Bo
Zhu, Peizhi
author_sort Wang, Jinyu
collection PubMed
description In this study, a novel biocompatible hydroxyapatite (HA) was synthesized by using chitosan oligosaccharide (COS) as a template. These HA samples were studied by Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), and transmission electron microscopy (TEM). The biocompatibility of HA samples was evaluated via cell viability, cell morphology and alkaline phosphatase staining of MG-63 cell lines. The results show that HA synthesized in the presence of COS was favorable to proliferation and osteogenic differentiation of MG-63 cells. These hydroxyapatites are potentially attractive biomaterials for bone tissue engineering applications.
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spelling pubmed-54588672017-07-28 Synthesis of Biocompatible Hydroxyapatite Using Chitosan Oligosaccharide as a Template Wang, Jinyu Liu, Guanxiong Chen, Jinshuai Zhao, Bo Zhu, Peizhi Materials (Basel) Article In this study, a novel biocompatible hydroxyapatite (HA) was synthesized by using chitosan oligosaccharide (COS) as a template. These HA samples were studied by Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), and transmission electron microscopy (TEM). The biocompatibility of HA samples was evaluated via cell viability, cell morphology and alkaline phosphatase staining of MG-63 cell lines. The results show that HA synthesized in the presence of COS was favorable to proliferation and osteogenic differentiation of MG-63 cells. These hydroxyapatites are potentially attractive biomaterials for bone tissue engineering applications. MDPI 2015-11-30 /pmc/articles/PMC5458867/ /pubmed/28793700 http://dx.doi.org/10.3390/ma8125440 Text en © 2015 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wang, Jinyu
Liu, Guanxiong
Chen, Jinshuai
Zhao, Bo
Zhu, Peizhi
Synthesis of Biocompatible Hydroxyapatite Using Chitosan Oligosaccharide as a Template
title Synthesis of Biocompatible Hydroxyapatite Using Chitosan Oligosaccharide as a Template
title_full Synthesis of Biocompatible Hydroxyapatite Using Chitosan Oligosaccharide as a Template
title_fullStr Synthesis of Biocompatible Hydroxyapatite Using Chitosan Oligosaccharide as a Template
title_full_unstemmed Synthesis of Biocompatible Hydroxyapatite Using Chitosan Oligosaccharide as a Template
title_short Synthesis of Biocompatible Hydroxyapatite Using Chitosan Oligosaccharide as a Template
title_sort synthesis of biocompatible hydroxyapatite using chitosan oligosaccharide as a template
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458867/
https://www.ncbi.nlm.nih.gov/pubmed/28793700
http://dx.doi.org/10.3390/ma8125440
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