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Molecular mechanisms underlying the pilsicainide-induced stabilization of hERG proteins in transfected mammalian cells

BACKGROUND: Pilsicainide, classified as a relatively selective Na(+) channel blocker, also has an inhibitory action on the rapidly-activating delayed-rectifier K(+) current (I(Kr)) through human ether-a-go-go-related gene (hERG) channels. We studied the effects of chronic exposure to pilsicainide on...

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Detalles Bibliográficos
Autores principales:	Onohara, Takeshi, Hisatome, Ichiro, Kurata, Yasutaka, Li, Peili, Notsu, Tomomi, Morikawa, Kumi, Otani, Naoyuki, Yoshida, Akio, Iitsuka, Kazuhiko, Kato, Masaru, Miake, Junichiro, Ninomiya, Haruaki, Higaki, Katsumi, Shirayoshi, Yasuaki, Nishihara, Takashi, Itoh, Toshiyuki, Nakamura, Yoshinobu, Nishimura, Motonobu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2017
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5459418/ https://www.ncbi.nlm.nih.gov/pubmed/28607619 http://dx.doi.org/10.1016/j.joa.2016.09.003

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