Cargando…

Role of LRRK2 in the regulation of dopamine receptor trafficking

Mutations in LRRK2 play a critical role in both familial and sporadic Parkinson’s disease (PD). Up to date, the role of LRRK2 in PD onset and progression remains largely unknown. However, experimental evidence highlights a critical role of LRRK2 in the control of vesicle trafficking that in turn may...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rassu, Mauro, Del Giudice, Maria Grazia, Sanna, Simona, Taymans, Jean Marc, Morari, Michele, Brugnoli, Alberto, Frassineti, Martina, Masala, Alessandra, Esposito, Sonia, Galioto, Manuela, Valle, Cristiana, Carri, Maria Teresa, Biosa, Alice, Greggio, Elisa, Crosio, Claudia, Iaccarino, Ciro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5459500/ https://www.ncbi.nlm.nih.gov/pubmed/28582422 http://dx.doi.org/10.1371/journal.pone.0179082

Ejemplares similares

Levetiracetam treatment ameliorates LRRK2 pathological mutant phenotype
por: Rassu, Mauro, et al.
Publicado: (2019)

LRRK2 Affects Vesicle Trafficking, Neurotransmitter Extracellular Level and Membrane Receptor Localization
por: Migheli, Rossana, et al.
Publicado: (2013)

Inhibition of the Exocyst Complex Attenuates the LRRK2 Pathological Effects
por: Ciampelli, Cristina, et al.
Publicado: (2023)

HDAC1 inhibition ameliorates TDP-43-induced cell death in vitro and in vivo
por: Sanna, Simona, et al.
Publicado: (2020)

Astroglial Inhibition of NF-κB Does Not Ameliorate Disease Onset and Progression in a Mouse Model for Amyotrophic Lateral Sclerosis (ALS)
por: Crosio, Claudia, et al.
Publicado: (2011)

LRRK2 Modulates the Exocyst Complex Assembly by Interacting with Sec8
por: Fais, Milena, et al.
Publicado: (2021)

Parkinson’s Disease-Related Genes and Lipid Alteration
por: Fais, Milena, et al.
Publicado: (2021)

Pharmacological LRRK2 kinase inhibition induces LRRK2 protein destabilization and proteasomal degradation
por: Lobbestael, E., et al.
Publicado: (2016)

LRRK2 Kinase Inhibition as a Therapeutic Strategy for Parkinson’s Disease, Where Do We Stand?
por: Taymans, Jean-Marc, et al.
Publicado: (2016)

The G2019S variant of leucine-rich repeat kinase 2 (LRRK2) alters endolysosomal trafficking by impairing the function of the GTPase RAB8A
por: Rivero-Ríos, Pilar, et al.
Publicado: (2019)

Age-dependent dopamine transporter dysfunction and Serine129 phospho-α-synuclein overload in G2019S LRRK2 mice
por: Longo, Francesco, et al.
Publicado: (2017)

LRRK2 kinase activity regulates synaptic vesicle trafficking and neurotransmitter release through modulation of LRRK2 macro-molecular complex
por: Cirnaru, Maria D., et al.
Publicado: (2014)

Single-step green synthesis and characterization of gold-conjugated polyphenol nanoparticles with antioxidant and biological activities
por: Sanna, Vanna, et al.
Publicado: (2014)

Leucine‐rich repeat kinase 2 (LRRK2) inhibitors differentially modulate glutamate release and Serine935 LRRK2 phosphorylation in striatal and cerebrocortical synaptosomes
por: Mercatelli, Daniela, et al.
Publicado: (2019)

Divergent Effects of G2019S and R1441C LRRK2 Mutations on LRRK2 and Rab10 Phosphorylations in Mouse Tissues
por: Iannotta, Lucia, et al.
Publicado: (2020)

Genetic and pharmacological evidence that G2019S LRRK2 confers a hyperkinetic phenotype, resistant to motor decline associated with aging
por: Longo, Francesco, et al.
Publicado: (2014)

The Parkinson's Disease Associated LRRK2 Exhibits Weaker In Vitro Phosphorylation of 4E-BP Compared to Autophosphorylation
por: Kumar, Azad, et al.
Publicado: (2010)

Trafficking of the glutamate transporter is impaired in LRRK2-related Parkinson’s disease
por: Iovino, Ludovica, et al.
Publicado: (2022)

Cyanobacteria, Cyanotoxins, and Neurodegenerative Diseases: Dangerous Liaisons
por: Sini, Paola, et al.
Publicado: (2021)

LRRK2 Kinase Activity Is Dependent on LRRK2 GTP Binding Capacity but Independent of LRRK2 GTP Binding
por: Taymans, Jean-Marc, et al.
Publicado: (2011)

LRRK2 modulates neuronal vesicles cycle through protein interactions
por: Piccoli, Giovanni, et al.
Publicado: (2015)

Autophagy and LRRK2 in the Aging Brain
por: Albanese, Federica, et al.
Publicado: (2019)

The LRRK2 Variant E193K Prevents Mitochondrial Fission Upon MPP+ Treatment by Altering LRRK2 Binding to DRP1
por: Perez Carrion, Maria, et al.
Publicado: (2018)

GTP binding regulates cellular localization of Parkinson's disease-associated LRRK2
por: Blanca Ramírez, Marian, et al.
Publicado: (2017)

Modeling Parkinson’s disease in LRRK2 rodents
por: Domenicale, Chiara, et al.
Publicado: (2023)

Dopamine D2 receptor-mediated neuroprotection in a G2019S Lrrk2 genetic model of Parkinson’s disease
por: Tozzi, Alessandro, et al.
Publicado: (2018)

LRRK2 and neuroinflammation: partners in crime in Parkinson’s disease?
por: Russo, Isabella, et al.
Publicado: (2014)

LRRK2 Phosphorylation, More Than an Epiphenomenon
por: Marchand, Antoine, et al.
Publicado: (2020)

Phosphatases of α-synuclein, LRRK2, and tau: important players in the phosphorylation-dependent pathology of Parkinsonism
por: Taymans, Jean-Marc, et al.
Publicado: (2014)

LRRK2 and membrane trafficking: nexus of Parkinson’s disease
por: Hur, Eun-Mi, et al.
Publicado: (2019)

Dopamine Transporter, PhosphoSerine129 α-Synuclein and α-Synuclein Levels in Aged LRRK2 G2019S Knock-In and Knock-Out Mice
por: Domenicale, Chiara, et al.
Publicado: (2022)

Mind the Gap: LRRK2 Phenotypes in the Clinic vs. in Patient Cells
por: Goveas, Liesel, et al.
Publicado: (2021)

Editorial: LRRK2—Fifteen Years From Cloning to the Clinic
por: Rideout, Hardy, et al.
Publicado: (2022)

Cryo-EM analysis of homodimeric full-length LRRK2 and LRRK1 protein complexes
por: Sejwal, Kushal, et al.
Publicado: (2017)

Perspective on the current state of the LRRK2 field
por: Taymans, Jean-Marc, et al.
Publicado: (2023)

Pathogenic LRRK2 requires secondary factors to induce cellular toxicity
por: Lobbestael, Evy, et al.
Publicado: (2020)

In silico, in vitro and cellular analysis with a kinome-wide inhibitor panel correlates cellular LRRK2 dephosphorylation to inhibitor activity on LRRK2
por: Vancraenenbroeck, Renée, et al.
Publicado: (2014)

Imaging dopamine function and microglia in asymptomatic LRRK2 mutation carriers
por: Gersel Stokholm, Morten, et al.
Publicado: (2020)

An Easy and Efficient Method for Native and Immunoreactive Echinococcus granulosus Antigen 5 Enrichment from Hydatid Cyst Fluid
por: Pagnozzi, Daniela, et al.
Publicado: (2014)

PAK6 Phosphorylates 14-3-3γ to Regulate Steady State Phosphorylation of LRRK2
por: Civiero, Laura, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_k2hldvs9o38nv7vnboobplaac5