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Tachycardia in patients treated with clozapine versus antipsychotic long-acting injections

Tachycardia is a known adverse effect during clozapine treatment. However, prevalence reported differs widely between studies and hitherto there are no studies comparing clozapine-treated patients with a similar control group. The present study was carried out to assess the prevalence of tachycardia...

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Autores principales: Nilsson, Björn M., Edström, Oscar, Lindström, Leif, Wernegren, Petter, Bodén, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams And Wilkins 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5459590/
https://www.ncbi.nlm.nih.gov/pubmed/28225439
http://dx.doi.org/10.1097/YIC.0000000000000169
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author Nilsson, Björn M.
Edström, Oscar
Lindström, Leif
Wernegren, Petter
Bodén, Robert
author_facet Nilsson, Björn M.
Edström, Oscar
Lindström, Leif
Wernegren, Petter
Bodén, Robert
author_sort Nilsson, Björn M.
collection PubMed
description Tachycardia is a known adverse effect during clozapine treatment. However, prevalence reported differs widely between studies and hitherto there are no studies comparing clozapine-treated patients with a similar control group. The present study was carried out to assess the prevalence of tachycardia in patients treated with clozapine and antipsychotic long-acting injections (LAI). Data on heart rate (HR), concomitant medication, and relevant anthropometric and laboratory measurements were collected for all clozapine-treated patients (n=174) in a defined catchment area and compared with data on patients treated with LAI (n=87). In total, 33% of patients on long-term clozapine treatment had tachycardia (HR>100) compared with 16% in the LAI group (P<0.001). The mean HR was 91 in the clozapine group and 82 in the LAI group (P<0.001). Clozapine dose correlated with HR. The majority of patients with HR more than 100 received no specific treatment for tachycardia. In conclusion, the prevalence of tachycardia was twice as high in patients treated with clozapine as in a similar patient group with severe schizophrenia spectrum disorder. The tachycardia was in many cases clinically unnoticed. Tachycardia during antipsychotic treatment is a common phenomenon that must be monitored for actively and, when noticed, further investigated and treated.
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spelling pubmed-54595902017-06-13 Tachycardia in patients treated with clozapine versus antipsychotic long-acting injections Nilsson, Björn M. Edström, Oscar Lindström, Leif Wernegren, Petter Bodén, Robert Int Clin Psychopharmacol Original Articles Tachycardia is a known adverse effect during clozapine treatment. However, prevalence reported differs widely between studies and hitherto there are no studies comparing clozapine-treated patients with a similar control group. The present study was carried out to assess the prevalence of tachycardia in patients treated with clozapine and antipsychotic long-acting injections (LAI). Data on heart rate (HR), concomitant medication, and relevant anthropometric and laboratory measurements were collected for all clozapine-treated patients (n=174) in a defined catchment area and compared with data on patients treated with LAI (n=87). In total, 33% of patients on long-term clozapine treatment had tachycardia (HR>100) compared with 16% in the LAI group (P<0.001). The mean HR was 91 in the clozapine group and 82 in the LAI group (P<0.001). Clozapine dose correlated with HR. The majority of patients with HR more than 100 received no specific treatment for tachycardia. In conclusion, the prevalence of tachycardia was twice as high in patients treated with clozapine as in a similar patient group with severe schizophrenia spectrum disorder. The tachycardia was in many cases clinically unnoticed. Tachycardia during antipsychotic treatment is a common phenomenon that must be monitored for actively and, when noticed, further investigated and treated. Lippincott Williams And Wilkins 2017-07 2017-06-01 /pmc/articles/PMC5459590/ /pubmed/28225439 http://dx.doi.org/10.1097/YIC.0000000000000169 Text en Copyright © 2017 The Author(s). Published by Wolters Kluwer Health, Inc. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/) (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/
spellingShingle Original Articles
Nilsson, Björn M.
Edström, Oscar
Lindström, Leif
Wernegren, Petter
Bodén, Robert
Tachycardia in patients treated with clozapine versus antipsychotic long-acting injections
title Tachycardia in patients treated with clozapine versus antipsychotic long-acting injections
title_full Tachycardia in patients treated with clozapine versus antipsychotic long-acting injections
title_fullStr Tachycardia in patients treated with clozapine versus antipsychotic long-acting injections
title_full_unstemmed Tachycardia in patients treated with clozapine versus antipsychotic long-acting injections
title_short Tachycardia in patients treated with clozapine versus antipsychotic long-acting injections
title_sort tachycardia in patients treated with clozapine versus antipsychotic long-acting injections
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5459590/
https://www.ncbi.nlm.nih.gov/pubmed/28225439
http://dx.doi.org/10.1097/YIC.0000000000000169
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