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Association between interleukin-8 levels and chronic periodontal disease: A PRISMA-compliant systematic review and meta-analysis
BACKGROUND: Current publications present contradictory findings regarding interleukin-8 (IL-8) levels in patients with chronic periodontitis (CP). This systematic review compile evidences of the IL8 mRNA and protein levels in gingival tissue, saliva, and gingival crevicular fluid (GCF) investigated...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5459707/ https://www.ncbi.nlm.nih.gov/pubmed/28562542 http://dx.doi.org/10.1097/MD.0000000000006932 |
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author | Finoti, Livia S Nepomuceno, Rafael Pigossi, Suzane C Corbi, Sâmia CT Secolin, Rodrigo Scarel-Caminaga, Raquel M. |
author_facet | Finoti, Livia S Nepomuceno, Rafael Pigossi, Suzane C Corbi, Sâmia CT Secolin, Rodrigo Scarel-Caminaga, Raquel M. |
author_sort | Finoti, Livia S |
collection | PubMed |
description | BACKGROUND: Current publications present contradictory findings regarding interleukin-8 (IL-8) levels in patients with chronic periodontitis (CP). This systematic review compile evidences of the IL8 mRNA and protein levels in gingival tissue, saliva, and gingival crevicular fluid (GCF) investigated in patients with CP. Moreover, 2 meta-analyses were made focusing on the IL-8 levels in GCF and saliva of patients with or without CP. METHODS: Electronic searches of the PubMed, Web of Science, and Scopus databases were conducted for publications up to February 2016 that investigated the levels of IL-8 detected in individuals with CP compared with health individuals. A total of 31 publications were included in the systematic review. For meta-analyses, the strength of association was calculated by pooled odds ratios with 95% confidence intervals using RevMan 5.1 software. Heterogeneity was examined using Higgins I-squared, tau-squared, and χ(2) tests. RESULTS: In biopsies of gingival tissue of CP patients, all studies found higher IL8 mRNA levels, and the majority of studies showed higher IL-8 protein levels in this tissue of individuals with moderate to severe CP. Four studies investigating the IL-8 levels in saliva showed inconclusive results. In spite of some studies seemed to indicate higher levels of IL-8 in GCF of CP patients, the meta-analysis results showed significantly lower IL-8 levels (pg/μL) in GCF of CP patients in comparison with periodontally healthy subjects. CONCLUSIONS: We concluded that IL8 gene expression and IL-8 protein levels were higher in gingival tissues of CP patients when compared to periodontally health individuals. Meta-analysis of studies that measured IL-8 (pg/uL) in GCF found lower levels in CP patients. There are conflicting evidences regarding IL-8 levels in saliva. |
format | Online Article Text |
id | pubmed-5459707 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-54597072017-06-12 Association between interleukin-8 levels and chronic periodontal disease: A PRISMA-compliant systematic review and meta-analysis Finoti, Livia S Nepomuceno, Rafael Pigossi, Suzane C Corbi, Sâmia CT Secolin, Rodrigo Scarel-Caminaga, Raquel M. Medicine (Baltimore) 3600 BACKGROUND: Current publications present contradictory findings regarding interleukin-8 (IL-8) levels in patients with chronic periodontitis (CP). This systematic review compile evidences of the IL8 mRNA and protein levels in gingival tissue, saliva, and gingival crevicular fluid (GCF) investigated in patients with CP. Moreover, 2 meta-analyses were made focusing on the IL-8 levels in GCF and saliva of patients with or without CP. METHODS: Electronic searches of the PubMed, Web of Science, and Scopus databases were conducted for publications up to February 2016 that investigated the levels of IL-8 detected in individuals with CP compared with health individuals. A total of 31 publications were included in the systematic review. For meta-analyses, the strength of association was calculated by pooled odds ratios with 95% confidence intervals using RevMan 5.1 software. Heterogeneity was examined using Higgins I-squared, tau-squared, and χ(2) tests. RESULTS: In biopsies of gingival tissue of CP patients, all studies found higher IL8 mRNA levels, and the majority of studies showed higher IL-8 protein levels in this tissue of individuals with moderate to severe CP. Four studies investigating the IL-8 levels in saliva showed inconclusive results. In spite of some studies seemed to indicate higher levels of IL-8 in GCF of CP patients, the meta-analysis results showed significantly lower IL-8 levels (pg/μL) in GCF of CP patients in comparison with periodontally healthy subjects. CONCLUSIONS: We concluded that IL8 gene expression and IL-8 protein levels were higher in gingival tissues of CP patients when compared to periodontally health individuals. Meta-analysis of studies that measured IL-8 (pg/uL) in GCF found lower levels in CP patients. There are conflicting evidences regarding IL-8 levels in saliva. Wolters Kluwer Health 2017-06-02 /pmc/articles/PMC5459707/ /pubmed/28562542 http://dx.doi.org/10.1097/MD.0000000000006932 Text en Copyright © 2017 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nd/4.0 This is an open access article distributed under the Creative Commons Attribution-No Derivatives License 4.0, which allows for redistribution, commercial and non-commercial, as long as it is passed along unchanged and in whole, with credit to the author. http://creativecommons.org/licenses/by-nd/4.0 |
spellingShingle | 3600 Finoti, Livia S Nepomuceno, Rafael Pigossi, Suzane C Corbi, Sâmia CT Secolin, Rodrigo Scarel-Caminaga, Raquel M. Association between interleukin-8 levels and chronic periodontal disease: A PRISMA-compliant systematic review and meta-analysis |
title | Association between interleukin-8 levels and chronic periodontal disease: A PRISMA-compliant systematic review and meta-analysis |
title_full | Association between interleukin-8 levels and chronic periodontal disease: A PRISMA-compliant systematic review and meta-analysis |
title_fullStr | Association between interleukin-8 levels and chronic periodontal disease: A PRISMA-compliant systematic review and meta-analysis |
title_full_unstemmed | Association between interleukin-8 levels and chronic periodontal disease: A PRISMA-compliant systematic review and meta-analysis |
title_short | Association between interleukin-8 levels and chronic periodontal disease: A PRISMA-compliant systematic review and meta-analysis |
title_sort | association between interleukin-8 levels and chronic periodontal disease: a prisma-compliant systematic review and meta-analysis |
topic | 3600 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5459707/ https://www.ncbi.nlm.nih.gov/pubmed/28562542 http://dx.doi.org/10.1097/MD.0000000000006932 |
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