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Inactivation of sortilin (a novel lysosomal sorting receptor) by dominant negative competition and RNA interference
To assess the role of sortilin in the sorting and trafficking of sphingolipid activator proteins (SAPs) the function of sortilin was abolished by a dominant-negative mutant and by the use of RNAi. Mutant sortilin lacking the carboxyl-terminal region that contains the sorting signal abolished the tra...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Biological Procedures Online
2005
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC545973/ https://www.ncbi.nlm.nih.gov/pubmed/15682222 http://dx.doi.org/10.1251/bpo101 |