RPA-Mediated Recruitment of the E3 Ligase RFWD3 Is Vital for Interstrand Crosslink Repair and Human Health

Defects in the repair of DNA interstrand crosslinks (ICLs) are associated with the genome instability syndrome Fanconi anemia (FA). Here we report that cells with mutations in RFWD3, an E3 ubiquitin ligase that interacts with and ubiquitylates replication protein A (RPA), show profound defects in IC...

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Detalles Bibliográficos
Autores principales: Feeney, Laura, Muñoz, Ivan M., Lachaud, Christophe, Toth, Rachel, Appleton, Paul L., Schindler, Detlev, Rouse, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5459755/
https://www.ncbi.nlm.nih.gov/pubmed/28575657
http://dx.doi.org/10.1016/j.molcel.2017.04.021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5459755/
https://www.ncbi.nlm.nih.gov/pubmed/28575657
http://dx.doi.org/10.1016/j.molcel.2017.04.021

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