Adipocyte Accumulation in the Bone Marrow during Obesity and Aging Impairs Stem Cell-Based Hematopoietic and Bone Regeneration

Aging and obesity induce ectopic adipocyte accumulation in bone marrow cavities. This process is thought to impair osteogenic and hematopoietic regeneration. Here we specify the cellular identities of the adipogenic and osteogenic lineages of the bone. While aging impairs the osteogenic lineage, hig...

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Detalles Bibliográficos
Autores principales: Ambrosi, Thomas H., Scialdone, Antonio, Graja, Antonia, Gohlke, Sabrina, Jank, Anne-Marie, Bocian, Carla, Woelk, Lena, Fan, Hua, Logan, Darren W., Schürmann, Annette, Saraiva, Luis R., Schulz, Tim J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5459794/
https://www.ncbi.nlm.nih.gov/pubmed/28330582
http://dx.doi.org/10.1016/j.stem.2017.02.009

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