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CRISPR/Cas9-mediated p53 and Pten dual mutation accelerates hepatocarcinogenesis in adult hepatitis B virus transgenic mice

The p53 mutation and altered Pten expression are two most common genetic events in Hepatitis B virus (HBV) infection related hepatocellular carcinoma (HCC). To confirm the causative role of p53 and Pten somatic mutation in HCC development, we established CRISPR/Cas9-mediated somatic gene disruption...

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Detalles Bibliográficos
Autores principales:	Liu, Yongzhen, Qi, Xuewei, Zeng, Zhenzhen, Wang, Lu, Wang, Jie, Zhang, Ting, Xu, Qiang, Shen, Congle, Zhou, Guangde, Yang, Shaomin, Chen, Xiangmei, Lu, Fengmin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5459841/ https://www.ncbi.nlm.nih.gov/pubmed/28584302 http://dx.doi.org/10.1038/s41598-017-03070-8

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