Cathepsin S inhibition combines control of systemic and peripheral pathomechanisms of autoimmune tissue injury

Cathepsin(Cat)-S processing of the invariant chain-MHC-II complex inside antigen presenting cells is a central pathomechanism of autoimmune-diseases. Additionally, Cat-S is released by activated-myeloid cells and was recently described to activate protease-activated-receptor-(PAR)-2 in extracellular...

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Detalles Bibliográficos
Autores principales: Tato, Maia, Kumar, Santhosh V., Liu, Yajuan, Mulay, Shrikant R., Moll, Solange, Popper, Bastian, Eberhard, Jonathan N., Thomasova, Dana, Rufer, Arne Christian, Gruner, Sabine, Haap, Wolfgang, Hartmann, Guido, Anders, Hans-Joachim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5459853/
https://www.ncbi.nlm.nih.gov/pubmed/28584258
http://dx.doi.org/10.1038/s41598-017-01894-y

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