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X-ray structures of fructosyl peptide oxidases revealing residues responsible for gating oxygen access in the oxidative half reaction

Current enzymatic systems for quantifying glycated hemoglobin are based on the FAD-containing enzyme fructosyl peptide oxidase (FPOX). FPOX has substrate specificity for fructosyl-(α) N-valyl-histidine derived from proteolytic digestion of the N-terminus of the HbA1c β-chain. This study reports the...

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Detalles Bibliográficos
Autores principales:	Shimasaki, Tomohisa, Yoshida, Hiromi, Kamitori, Shigehiro, Sode, Koji
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5459902/ https://www.ncbi.nlm.nih.gov/pubmed/28584265 http://dx.doi.org/10.1038/s41598-017-02657-5

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