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Inconsistency in Abnormal Brain Activity across Cohorts of ADHD-200 in Children with Attention Deficit Hyperactivity Disorder

Many papers have shown results from the multi-site dataset of resting-state fMRI (rs-fMRI) in attention deficit hyperactivity disorder (ADHD), a data-sharing project named ADHD-200. However, few studies have illustrated that to what extent the pooled findings were consistent across cohorts. The pres...

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Autores principales: Wang, Jian-Bao, Zheng, Li-Jun, Cao, Qing-Jiu, Wang, Yu-Feng, Sun, Li, Zang, Yu-Feng, Zhang, Hang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5459906/
https://www.ncbi.nlm.nih.gov/pubmed/28634439
http://dx.doi.org/10.3389/fnins.2017.00320
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author Wang, Jian-Bao
Zheng, Li-Jun
Cao, Qing-Jiu
Wang, Yu-Feng
Sun, Li
Zang, Yu-Feng
Zhang, Hang
author_facet Wang, Jian-Bao
Zheng, Li-Jun
Cao, Qing-Jiu
Wang, Yu-Feng
Sun, Li
Zang, Yu-Feng
Zhang, Hang
author_sort Wang, Jian-Bao
collection PubMed
description Many papers have shown results from the multi-site dataset of resting-state fMRI (rs-fMRI) in attention deficit hyperactivity disorder (ADHD), a data-sharing project named ADHD-200. However, few studies have illustrated that to what extent the pooled findings were consistent across cohorts. The present study analyzed three voxel-wise whole-brain metrics, i.e., amplitude of low-frequency fluctuation (ALFF), regional homogeneity (ReHo), and degree centrality (DC) based on the pooled dataset as well as individual cohort of ADHD-200. In addition to the conventional frequency band of 0.01–0.08 Hz, sub-frequency bands of 0–0.01, 0.01–0.027, 0.027–0.073, 0.073–0.198, and 0.198–0.25 Hz, were assessed. While the pooled dataset showed abnormal activity in some brain regions, e.g., the bilateral sensorimotor cortices, bilateral cerebellum, and the bilateral lingual gyrus, these results were highly inconsistent across cohorts, even across the three cohorts from the same research center. The standardized effect size was rather small. These findings suggested a high heterogeneity of spontaneous brain activity in ADHD. Future studies based on multi-site large-sample dataset should be performed on pooled data and single cohort data, respectively and the effect size must be shown.
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spelling pubmed-54599062017-06-20 Inconsistency in Abnormal Brain Activity across Cohorts of ADHD-200 in Children with Attention Deficit Hyperactivity Disorder Wang, Jian-Bao Zheng, Li-Jun Cao, Qing-Jiu Wang, Yu-Feng Sun, Li Zang, Yu-Feng Zhang, Hang Front Neurosci Neuroscience Many papers have shown results from the multi-site dataset of resting-state fMRI (rs-fMRI) in attention deficit hyperactivity disorder (ADHD), a data-sharing project named ADHD-200. However, few studies have illustrated that to what extent the pooled findings were consistent across cohorts. The present study analyzed three voxel-wise whole-brain metrics, i.e., amplitude of low-frequency fluctuation (ALFF), regional homogeneity (ReHo), and degree centrality (DC) based on the pooled dataset as well as individual cohort of ADHD-200. In addition to the conventional frequency band of 0.01–0.08 Hz, sub-frequency bands of 0–0.01, 0.01–0.027, 0.027–0.073, 0.073–0.198, and 0.198–0.25 Hz, were assessed. While the pooled dataset showed abnormal activity in some brain regions, e.g., the bilateral sensorimotor cortices, bilateral cerebellum, and the bilateral lingual gyrus, these results were highly inconsistent across cohorts, even across the three cohorts from the same research center. The standardized effect size was rather small. These findings suggested a high heterogeneity of spontaneous brain activity in ADHD. Future studies based on multi-site large-sample dataset should be performed on pooled data and single cohort data, respectively and the effect size must be shown. Frontiers Media S.A. 2017-06-06 /pmc/articles/PMC5459906/ /pubmed/28634439 http://dx.doi.org/10.3389/fnins.2017.00320 Text en Copyright © 2017 Wang, Zheng, Cao, Wang, Sun, Zang and Zhang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Wang, Jian-Bao
Zheng, Li-Jun
Cao, Qing-Jiu
Wang, Yu-Feng
Sun, Li
Zang, Yu-Feng
Zhang, Hang
Inconsistency in Abnormal Brain Activity across Cohorts of ADHD-200 in Children with Attention Deficit Hyperactivity Disorder
title Inconsistency in Abnormal Brain Activity across Cohorts of ADHD-200 in Children with Attention Deficit Hyperactivity Disorder
title_full Inconsistency in Abnormal Brain Activity across Cohorts of ADHD-200 in Children with Attention Deficit Hyperactivity Disorder
title_fullStr Inconsistency in Abnormal Brain Activity across Cohorts of ADHD-200 in Children with Attention Deficit Hyperactivity Disorder
title_full_unstemmed Inconsistency in Abnormal Brain Activity across Cohorts of ADHD-200 in Children with Attention Deficit Hyperactivity Disorder
title_short Inconsistency in Abnormal Brain Activity across Cohorts of ADHD-200 in Children with Attention Deficit Hyperactivity Disorder
title_sort inconsistency in abnormal brain activity across cohorts of adhd-200 in children with attention deficit hyperactivity disorder
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5459906/
https://www.ncbi.nlm.nih.gov/pubmed/28634439
http://dx.doi.org/10.3389/fnins.2017.00320
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