Alexander Disease Mutations Produce Cells with Coexpression of Glial Fibrillary Acidic Protein and NG2 in Neurosphere Cultures and Inhibit Differentiation into Mature Oligodendrocytes

BACKGROUND: Alexander disease (AxD) is a rare disease caused by mutations in the gene encoding glial fibrillary acidic protein (GFAP). The disease is characterized by presence of GFAP aggregates in the cytoplasm of astrocytes and loss of myelin. OBJECTIVES: Determine the effect of AxD-related mutati...

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Autores principales: Gómez-Pinedo, Ulises, Sirerol-Piquer, Maria Salomé, Durán-Moreno, María, García-Verdugo, José Manuel, Matias-Guiu, Jorge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5459916/
https://www.ncbi.nlm.nih.gov/pubmed/28634469
http://dx.doi.org/10.3389/fneur.2017.00255

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