Common Genetic Variant of INSIG2 Gene rs7566605 Polymorphism Is Associated with Severe Obesity in North India

BACKGROUND: Obesity is a very common disorder resulting from an imbalance between food intake and energy expenditure, and it has a substantial impact on the development of chronic diseases. The aim of this study was to examine the association of INSIG2 (rs7566605) gene polymorphism with obesity and...

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Autores principales: Prakash, Jai, Mittal, Balraj, Srivastava, Apurva, Awasthi, Shally, Srivastava, Pranjal, Srivastava, Neena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pasteur Institute 2017
Materias:
Full Length
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5459941/
https://www.ncbi.nlm.nih.gov/pubmed/28160769
http://dx.doi.org/10.18869/acadpub.ibj.21.4.261
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author Prakash, Jai
Mittal, Balraj
Srivastava, Apurva
Awasthi, Shally
Srivastava, Pranjal
Srivastava, Neena
author_facet Prakash, Jai
Mittal, Balraj
Srivastava, Apurva
Awasthi, Shally
Srivastava, Pranjal
Srivastava, Neena
author_sort Prakash, Jai
collection PubMed
description BACKGROUND: Obesity is a very common disorder resulting from an imbalance between food intake and energy expenditure, and it has a substantial impact on the development of chronic diseases. The aim of this study was to examine the association of INSIG2 (rs7566605) gene polymorphism with obesity and obesity associated phenotypes in North Indian subjects. METHODS: The variants were investigated for association in 642 obese and non-obese individuals. The genotyping of INSIG2 (rs7566605) single nucleotide polymorphism was analyzed by the TaqMan allelic discrimination protocol. RESULTS: A significant association was observed for INSIG2 (rs7566605) single nucleotide polymorphism with obesity and obesity-related phenotypes. Furthermore, a significant relationship was found between the rs7566605 and insulin, homeostasis model of assessment-insulin resistance, the percentage of body fat, fat mass, leptin, and adiponectin. CONCLUSION: The present study observed significant association between INSIG2 (rs7566605) single nucleotide polymorphism and obesity, as well as obesity-associated phenotypes in North Indian population.
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spelling pubmed-54599412017-07-01 Common Genetic Variant of INSIG2 Gene rs7566605 Polymorphism Is Associated with Severe Obesity in North India Prakash, Jai Mittal, Balraj Srivastava, Apurva Awasthi, Shally Srivastava, Pranjal Srivastava, Neena Iran Biomed J Full Length BACKGROUND: Obesity is a very common disorder resulting from an imbalance between food intake and energy expenditure, and it has a substantial impact on the development of chronic diseases. The aim of this study was to examine the association of INSIG2 (rs7566605) gene polymorphism with obesity and obesity associated phenotypes in North Indian subjects. METHODS: The variants were investigated for association in 642 obese and non-obese individuals. The genotyping of INSIG2 (rs7566605) single nucleotide polymorphism was analyzed by the TaqMan allelic discrimination protocol. RESULTS: A significant association was observed for INSIG2 (rs7566605) single nucleotide polymorphism with obesity and obesity-related phenotypes. Furthermore, a significant relationship was found between the rs7566605 and insulin, homeostasis model of assessment-insulin resistance, the percentage of body fat, fat mass, leptin, and adiponectin. CONCLUSION: The present study observed significant association between INSIG2 (rs7566605) single nucleotide polymorphism and obesity, as well as obesity-associated phenotypes in North Indian population. Pasteur Institute 2017-07 /pmc/articles/PMC5459941/ /pubmed/28160769 http://dx.doi.org/10.18869/acadpub.ibj.21.4.261 Text en Copyright: © Iranian Biomedical Journal http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Full Length
Prakash, Jai
Mittal, Balraj
Srivastava, Apurva
Awasthi, Shally
Srivastava, Pranjal
Srivastava, Neena
Common Genetic Variant of INSIG2 Gene rs7566605 Polymorphism Is Associated with Severe Obesity in North India
title Common Genetic Variant of INSIG2 Gene rs7566605 Polymorphism Is Associated with Severe Obesity in North India
title_full Common Genetic Variant of INSIG2 Gene rs7566605 Polymorphism Is Associated with Severe Obesity in North India
title_fullStr Common Genetic Variant of INSIG2 Gene rs7566605 Polymorphism Is Associated with Severe Obesity in North India
title_full_unstemmed Common Genetic Variant of INSIG2 Gene rs7566605 Polymorphism Is Associated with Severe Obesity in North India
title_short Common Genetic Variant of INSIG2 Gene rs7566605 Polymorphism Is Associated with Severe Obesity in North India
title_sort common genetic variant of insig2 gene rs7566605 polymorphism is associated with severe obesity in north india
topic Full Length
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5459941/
https://www.ncbi.nlm.nih.gov/pubmed/28160769
http://dx.doi.org/10.18869/acadpub.ibj.21.4.261
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