TGF-β activation by bone marrow-derived thrombospondin-1 causes Schistosoma- and hypoxia-induced pulmonary hypertension

Pulmonary arterial hypertension (PAH) is an obstructive disease of the precapillary pulmonary arteries. Schistosomiasis-associated PAH shares altered vascular TGF-β signalling with idiopathic, heritable and autoimmune-associated etiologies; moreover, TGF-β blockade can prevent experimental pulmonary...

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Detalles Bibliográficos
Autores principales: Kumar, Rahul, Mickael, Claudia, Kassa, Biruk, Gebreab, Liya, Robinson, Jeffrey C., Koyanagi, Daniel E., Sanders, Linda, Barthel, Lea, Meadows, Christina, Fox, Daniel, Irwin, David, Li, Min, McKeon, B. Alexandre, Riddle, Suzette, Dale Brown, R., Morgan, Leslie E., Evans, Christopher M., Hernandez-Saavedra, Daniel, Bandeira, Angela, Maloney, James P., Bull, Todd M., Janssen, William J., Stenmark, Kurt R., Tuder, Rubin M., Graham, Brian B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5459967/
https://www.ncbi.nlm.nih.gov/pubmed/28555642
http://dx.doi.org/10.1038/ncomms15494

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