Systematic discovery of mutation-specific synthetic lethals by mining pan-cancer human primary tumor data

Two genes are synthetically lethal (SL) when defects in both are lethal to a cell but a single defect is non-lethal. SL partners of cancer mutations are of great interest as pharmacological targets; however, identifying them by cell line-based methods is challenging. Here we develop MiSL (Mining Syn...

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Detalles Bibliográficos
Autores principales: Sinha, Subarna, Thomas, Daniel, Chan, Steven, Gao, Yang, Brunen, Diede, Torabi, Damoun, Reinisch, Andreas, Hernandez, David, Chan, Andy, Rankin, Erinn B., Bernards, Rene, Majeti, Ravindra, Dill, David L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460027/
https://www.ncbi.nlm.nih.gov/pubmed/28561042
http://dx.doi.org/10.1038/ncomms15580

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