WIPI3 and WIPI4 β-propellers are scaffolds for LKB1-AMPK-TSC signalling circuits in the control of autophagy

Autophagy is controlled by AMPK and mTOR, both of which associate with ULK1 and control the production of phosphatidylinositol 3-phosphate (PtdIns3P), a prerequisite for autophagosome formation. Here we report that WIPI3 and WIPI4 scaffold the signal control of autophagy upstream of PtdIns3P product...

Descripción completa

Detalles Bibliográficos
Autores principales: Bakula, Daniela, Müller, Amelie J., Zuleger, Theresia, Takacs, Zsuzsanna, Franz-Wachtel, Mirita, Thost, Ann-Katrin, Brigger, Daniel, Tschan, Mario P., Frickey, Tancred, Robenek, Horst, Macek, Boris, Proikas-Cezanne, Tassula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460038/
https://www.ncbi.nlm.nih.gov/pubmed/28561066
http://dx.doi.org/10.1038/ncomms15637

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460038/
https://www.ncbi.nlm.nih.gov/pubmed/28561066
http://dx.doi.org/10.1038/ncomms15637

Ejemplares similares