Cargando…

WIPI3 and WIPI4 β-propellers are scaffolds for LKB1-AMPK-TSC signalling circuits in the control of autophagy

Autophagy is controlled by AMPK and mTOR, both of which associate with ULK1 and control the production of phosphatidylinositol 3-phosphate (PtdIns3P), a prerequisite for autophagosome formation. Here we report that WIPI3 and WIPI4 scaffold the signal control of autophagy upstream of PtdIns3P product...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bakula, Daniela, Müller, Amelie J., Zuleger, Theresia, Takacs, Zsuzsanna, Franz-Wachtel, Mirita, Thost, Ann-Katrin, Brigger, Daniel, Tschan, Mario P., Frickey, Tancred, Robenek, Horst, Macek, Boris, Proikas-Cezanne, Tassula
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460038/ https://www.ncbi.nlm.nih.gov/pubmed/28561066 http://dx.doi.org/10.1038/ncomms15637

Ejemplares similares

Freeze-fracture replica immunolabelling reveals human WIPI-1 and WIPI-2 as membrane proteins of autophagosomes
por: Proikas-Cezanne, Tassula, et al.
Publicado: (2011)

WIPI-Mediated Autophagy and Longevity
por: Grimmel, Mona, et al.
Publicado: (2015)

WIPI-dependent autophagy during neutrophil differentiation of NB4 acute promyelocytic leukemia cells
por: Brigger, D, et al.
Publicado: (2014)

Defining regulatory and phosphoinositide-binding sites in the human WIPI-1 β-propeller responsible for autophagosomal membrane localization downstream of mTORC1 inhibition
por: Gaugel, Anja, et al.
Publicado: (2012)

WIPI-1 Positive Autophagosome-Like Vesicles Entrap Pathogenic Staphylococcus aureus for Lysosomal Degradation
por: Mauthe, Mario, et al.
Publicado: (2012)

The ABL-MYC axis controls WIPI1-enhanced autophagy in lifespan extension
por: Sporbeck, Katharina, et al.
Publicado: (2023)

SGK1 Inhibits Autophagy in Murine Muscle Tissue
por: Zuleger, Theresia, et al.
Publicado: (2018)

Multi-site-mediated entwining of the linear WIR-motif around WIPI β-propellers for autophagy
por: Ren, Jinqi, et al.
Publicado: (2020)

WIPI proteins: Biological functions and related syndromes
por: Almannai, Mohammed, et al.
Publicado: (2022)

Comprehensive analysis of autophagic functions of WIPI family proteins and their implications for the pathogenesis of β-propeller associated neurodegeneration
por: Shimizu, Takahiro, et al.
Publicado: (2023)

TBK1 directs WIPI2 against Salmonella
por: Boyle, Keith B., et al.
Publicado: (2016)

Wipi3 is essential for alternative autophagy and its loss causes neurodegeneration
por: Yamaguchi, Hirofumi, et al.
Publicado: (2020)

WIPI2 positively regulates mitophagy by promoting mitochondrial recruitment of VCP
por: Lu, Guang, et al.
Publicado: (2022)

Systemic Expression Analysis Reveals Prognostic Significance of WIPI3 in Hepatocellular Carcinoma
por: Liang, Tao-tao, et al.
Publicado: (2020)

The WIPI Gene Family and Neurodegenerative Diseases: Insights From Yeast and Dictyostelium Models
por: Vincent, Olivier, et al.
Publicado: (2021)

A conserved ATG2 binding site in WIPI4 and yeast Hsv2 is disrupted by mutations causing β-propeller protein-associated neurodegeneration
por: Bueno-Arribas, Miranda, et al.
Publicado: (2021)

Expression of WIPI2B counteracts age-related decline in autophagosome biogenesis in neurons
por: Stavoe, Andrea KH, et al.
Publicado: (2019)

A mutation in the major autophagy gene, WIPI2, associated with global developmental abnormalities
por: Jelani, Musharraf, et al.
Publicado: (2019)

Structural basis for membrane recruitment of ATG16L1 by WIPI2 in autophagy
por: Strong, Lisa M, et al.
Publicado: (2021)

Recruitment of TBK1 to cytosol‐invading Salmonella induces WIPI2‐dependent antibacterial autophagy
por: Thurston, Teresa LM, et al.
Publicado: (2016)

WIPI1, BAG1, and PEX3 Autophagy-Related Genes Are Relevant Melanoma Markers
por: D'Arcangelo, Daniela, et al.
Publicado: (2018)

WIPI2 depletion inhibits the growth of hepatocellular carcinoma cells through the AMPK signaling pathway
por: Liu, Chunsheng, et al.
Publicado: (2020)

WIPI1 promotes fission of endosomal transport carriers and formation of autophagosomes through distinct mechanisms
por: De Leo, Maria Giovanna, et al.
Publicado: (2021)

Drp1 modulates mitochondrial stress responses to mitotic arrest
por: Peña-Blanco, Aida, et al.
Publicado: (2020)

Correction: Drp1 modulates mitochondrial stress responses to mitotic arrest
por: Peña-Blanco, Aida, et al.
Publicado: (2021)

ATG-18 and EPG-6 are Both Required for Autophagy but Differentially Contribute to Lifespan Control in Caenorhabditis elegans
por: Takacs, Zsuzsanna, et al.
Publicado: (2019)

Coincidence detection of RAB11A and PI(3)P by WIPI2 directs autophagosome formation
por: Vicinanza, Mariella, et al.
Publicado: (2019)

WIPI2 enhances the vulnerability of colorectal cancer cells to erastin via bioinformatics analysis and experimental verification
por: Yu, Liying, et al.
Publicado: (2023)

Editorial: Autophagy and Ageing: Ideas, Methods, Molecules
por: Proikas-Cezanne, Tassula, et al.
Publicado: (2020)

Characterisation of two Toxoplasma PROPPINs homologous to Atg18/WIPI suggests they have evolved distinct specialised functions
por: Nguyen, Hoa Mai, et al.
Publicado: (2018)

A PI3K-WIPI2 positive feedback loop allosterically activates LC3 lipidation in autophagy
por: Fracchiolla, Dorotea, et al.
Publicado: (2020)

ATG16L1 adopts a dual–binding site mode to interact with WIPI2b in autophagy
por: Gong, Xinyu, et al.
Publicado: (2023)

Identification of protein tyrosine phosphatase 1B and casein as substrates for 124-v-Mos
por: Proikas-Cezanne, Tassula, et al.
Publicado: (2002)

Homozygous missense WIPI2 variants cause a congenital disorder of autophagy with neurodevelopmental impairments of variable clinical severity and disease course
por: Maroofian, Reza, et al.
Publicado: (2021)

WIPI2 Links LC3 Conjugation with PI3P, Autophagosome Formation, and Pathogen Clearance by Recruiting Atg12–5-16L1
por: Dooley, Hannah C., et al.
Publicado: (2014)

The RAB11A-Positive Compartment Is a Primary Platform for Autophagosome Assembly Mediated by WIPI2 Recognition of PI3P-RAB11A
por: Puri, Claudia, et al.
Publicado: (2018)

Lysosome docking to WIPI1 rings and ER-connected phagophores occurs during DNAJB12- and GABARAP-dependent selective autophagy of misfolded P23H-rhodopsin
por: Kennedy, Andrew, et al.
Publicado: (2022)

Transautophagy: Research and Translation of Autophagy Knowledge
por: Albertini, Maria C., et al.
Publicado: (2018)

Transautophagy: Research and Translation of Autophagy Knowledge 2020
por: Engedal, Nikolai, et al.
Publicado: (2022)

Autophagy profiling in single cells with open source CellProfiler-based image analysis
por: Schüssele, David S., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_5f1l0680baa9ilml7qfrse8p9t