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Vitamin D ointment for prevention of radiation dermatitis in breast cancer patients

Radiation dermatitis occurs frequently during adjuvant radiation therapy for breast cancer. Prevention of radiation dermatitis by applying various creams and ointments has a limited success, and Aqua cream which has urea as one of its active ingredients is used in many institutions as a preventive t...

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Autores principales: Nasser, Nicola J., Fenig, Shlomit, Ravid, Amiram, Nouriel, Ariella, Ozery, Naama, Gardyn, Sara, Koren, Ruth, Fenig, Eyal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460188/
https://www.ncbi.nlm.nih.gov/pubmed/28649650
http://dx.doi.org/10.1038/s41523-017-0006-x
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author Nasser, Nicola J.
Fenig, Shlomit
Ravid, Amiram
Nouriel, Ariella
Ozery, Naama
Gardyn, Sara
Koren, Ruth
Fenig, Eyal
author_facet Nasser, Nicola J.
Fenig, Shlomit
Ravid, Amiram
Nouriel, Ariella
Ozery, Naama
Gardyn, Sara
Koren, Ruth
Fenig, Eyal
author_sort Nasser, Nicola J.
collection PubMed
description Radiation dermatitis occurs frequently during adjuvant radiation therapy for breast cancer. Prevention of radiation dermatitis by applying various creams and ointments has a limited success, and Aqua cream which has urea as one of its active ingredients is used in many institutions as a preventive treatment. The primary goal of this study is to assess the effect of vitamin D (calcipotriol) ointment in prevention of radiodermatitis in breast cancer patients compared to Aqua cream. Twenty-three women with localized breast cancer who underwent breast-conserving surgery and opted to receive adjuvant radiotherapy to breast only were enrolled in this study. A cream containing an active vitamin D analog, calcipotriol (Daivonex), was randomly applied either to the medial or to the lateral half of the irradiated breast, while Aqua cream was applied to the complimentary half of the same breast along the whole treatment days, each day, after the delivery of radiation. Skin reaction was recorded and compared between the two halves of the breast. Vitamin D was well tolerated by patients with no local or systemic allergic reactions. Radiation dermatitis was not significantly different between both treatment arms. Topical vitamin D ointment is not superior to Aqua cream for prevention of radiation-induced dermatitis in women treated with adjuvant radiation for breast cancer.
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spelling pubmed-54601882017-06-23 Vitamin D ointment for prevention of radiation dermatitis in breast cancer patients Nasser, Nicola J. Fenig, Shlomit Ravid, Amiram Nouriel, Ariella Ozery, Naama Gardyn, Sara Koren, Ruth Fenig, Eyal NPJ Breast Cancer Article Radiation dermatitis occurs frequently during adjuvant radiation therapy for breast cancer. Prevention of radiation dermatitis by applying various creams and ointments has a limited success, and Aqua cream which has urea as one of its active ingredients is used in many institutions as a preventive treatment. The primary goal of this study is to assess the effect of vitamin D (calcipotriol) ointment in prevention of radiodermatitis in breast cancer patients compared to Aqua cream. Twenty-three women with localized breast cancer who underwent breast-conserving surgery and opted to receive adjuvant radiotherapy to breast only were enrolled in this study. A cream containing an active vitamin D analog, calcipotriol (Daivonex), was randomly applied either to the medial or to the lateral half of the irradiated breast, while Aqua cream was applied to the complimentary half of the same breast along the whole treatment days, each day, after the delivery of radiation. Skin reaction was recorded and compared between the two halves of the breast. Vitamin D was well tolerated by patients with no local or systemic allergic reactions. Radiation dermatitis was not significantly different between both treatment arms. Topical vitamin D ointment is not superior to Aqua cream for prevention of radiation-induced dermatitis in women treated with adjuvant radiation for breast cancer. Nature Publishing Group UK 2017-03-31 /pmc/articles/PMC5460188/ /pubmed/28649650 http://dx.doi.org/10.1038/s41523-017-0006-x Text en © The Author(s) 2017 This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Nasser, Nicola J.
Fenig, Shlomit
Ravid, Amiram
Nouriel, Ariella
Ozery, Naama
Gardyn, Sara
Koren, Ruth
Fenig, Eyal
Vitamin D ointment for prevention of radiation dermatitis in breast cancer patients
title Vitamin D ointment for prevention of radiation dermatitis in breast cancer patients
title_full Vitamin D ointment for prevention of radiation dermatitis in breast cancer patients
title_fullStr Vitamin D ointment for prevention of radiation dermatitis in breast cancer patients
title_full_unstemmed Vitamin D ointment for prevention of radiation dermatitis in breast cancer patients
title_short Vitamin D ointment for prevention of radiation dermatitis in breast cancer patients
title_sort vitamin d ointment for prevention of radiation dermatitis in breast cancer patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460188/
https://www.ncbi.nlm.nih.gov/pubmed/28649650
http://dx.doi.org/10.1038/s41523-017-0006-x
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