PHLDA3 impedes somatic cell reprogramming by activating Akt-GSK3β pathway

Reprogramming of adult somatic cells into induced pluripotent stem cells holds great promise in clinical therapy. Increasing evidences have shown that p53 and its target genes play important roles in somatic cell reprogramming. In this study, we report that PHLDA3, a p53 target gene, functions as a...

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Detalles Bibliográficos
Autores principales: Qiao, Mengran, Wu, Mian, Shi, Ronghua, Hu, Wanglai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460190/
https://www.ncbi.nlm.nih.gov/pubmed/28588267
http://dx.doi.org/10.1038/s41598-017-02982-9
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author Qiao, Mengran
Wu, Mian
Shi, Ronghua
Hu, Wanglai
author_facet Qiao, Mengran
Wu, Mian
Shi, Ronghua
Hu, Wanglai
author_sort Qiao, Mengran
collection PubMed
description Reprogramming of adult somatic cells into induced pluripotent stem cells holds great promise in clinical therapy. Increasing evidences have shown that p53 and its target genes play important roles in somatic cell reprogramming. In this study, we report that PHLDA3, a p53 target gene, functions as a blockage of iPSCs generation by activating the Akt-GSK3β pathway. Furthermore, PHLDA3 is found to be transcriptionally regulated by Oct4. These findings reveal that PHLDA3 acts as a new member of the regulatory network of somatic cell reprogramming.
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spelling pubmed-54601902017-06-06 PHLDA3 impedes somatic cell reprogramming by activating Akt-GSK3β pathway Qiao, Mengran Wu, Mian Shi, Ronghua Hu, Wanglai Sci Rep Article Reprogramming of adult somatic cells into induced pluripotent stem cells holds great promise in clinical therapy. Increasing evidences have shown that p53 and its target genes play important roles in somatic cell reprogramming. In this study, we report that PHLDA3, a p53 target gene, functions as a blockage of iPSCs generation by activating the Akt-GSK3β pathway. Furthermore, PHLDA3 is found to be transcriptionally regulated by Oct4. These findings reveal that PHLDA3 acts as a new member of the regulatory network of somatic cell reprogramming. Nature Publishing Group UK 2017-06-06 /pmc/articles/PMC5460190/ /pubmed/28588267 http://dx.doi.org/10.1038/s41598-017-02982-9 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Qiao, Mengran
Wu, Mian
Shi, Ronghua
Hu, Wanglai
PHLDA3 impedes somatic cell reprogramming by activating Akt-GSK3β pathway
title PHLDA3 impedes somatic cell reprogramming by activating Akt-GSK3β pathway
title_full PHLDA3 impedes somatic cell reprogramming by activating Akt-GSK3β pathway
title_fullStr PHLDA3 impedes somatic cell reprogramming by activating Akt-GSK3β pathway
title_full_unstemmed PHLDA3 impedes somatic cell reprogramming by activating Akt-GSK3β pathway
title_short PHLDA3 impedes somatic cell reprogramming by activating Akt-GSK3β pathway
title_sort phlda3 impedes somatic cell reprogramming by activating akt-gsk3β pathway
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460190/
https://www.ncbi.nlm.nih.gov/pubmed/28588267
http://dx.doi.org/10.1038/s41598-017-02982-9
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