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PHLDA3 impedes somatic cell reprogramming by activating Akt-GSK3β pathway
Reprogramming of adult somatic cells into induced pluripotent stem cells holds great promise in clinical therapy. Increasing evidences have shown that p53 and its target genes play important roles in somatic cell reprogramming. In this study, we report that PHLDA3, a p53 target gene, functions as a...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460190/ https://www.ncbi.nlm.nih.gov/pubmed/28588267 http://dx.doi.org/10.1038/s41598-017-02982-9 |