A Central Small Amino Acid in the VAMP2 Transmembrane Domain Regulates the Fusion Pore in Exocytosis

Exocytosis depends on cytosolic domains of SNARE proteins but the function of the transmembrane domains (TMDs) in membrane fusion remains controversial. The TMD of the SNARE protein synaptobrevin2/VAMP2 contains two highly conserved small amino acids, G(100) and C(103), in its central portion. Subst...

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Detalles Bibliográficos
Autores principales: Hastoy, Benoît, Scotti, Pier A., Milochau, Alexandra, Fezoua-Boubegtiten, Zahia, Rodas, Jorge, Megret, Rémi, Desbat, Bernard, Laguerre, Michel, Castano, Sabine, Perrais, David, Rorsman, Patrik, Oda, Reiko, Lang, Jochen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460238/
https://www.ncbi.nlm.nih.gov/pubmed/28588281
http://dx.doi.org/10.1038/s41598-017-03013-3

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