Identification of New Shikonin Derivatives as Antitumor Agents Targeting STAT3 SH2 Domain

Signal transducer and activator of transcription 3 (STAT3) is hyper-activated in diversiform human tumors and has been validated as an attractive therapeutic target. Current research showed that a natural product, shikonin, along with its synthetic analogues, is able to inhibit the activity of STAT3...

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Detalles Bibliográficos
Autores principales: Qiu, Han-Yue, Zhu, Xiang, Luo, Yue-Lin, Lin, Hong-Yan, Tang, Cheng-Yi, Qi, Jin-Liang, Pang, Yan-Jun, Yang, Rong-Wu, Lu, Gui-Hua, Wang, Xiao-Ming, Yang, Yong-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460289/
https://www.ncbi.nlm.nih.gov/pubmed/28588262
http://dx.doi.org/10.1038/s41598-017-02671-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460289/
https://www.ncbi.nlm.nih.gov/pubmed/28588262
http://dx.doi.org/10.1038/s41598-017-02671-7

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