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Identification of New Shikonin Derivatives as Antitumor Agents Targeting STAT3 SH2 Domain
Signal transducer and activator of transcription 3 (STAT3) is hyper-activated in diversiform human tumors and has been validated as an attractive therapeutic target. Current research showed that a natural product, shikonin, along with its synthetic analogues, is able to inhibit the activity of STAT3...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460289/ https://www.ncbi.nlm.nih.gov/pubmed/28588262 http://dx.doi.org/10.1038/s41598-017-02671-7 |