Role of mesenchymal stem cells, their derived factors, and extracellular vesicles in liver failure

Liver failure is a severe clinical syndrome with a poor prognosis. Mesenchymal stem cell (MSC) transplantation has emerged as a new intervention in treating liver failure. It is conventionally recognized that MSCs exert their therapeutic effect mainly through transdifferentiation. Recently, publishe...

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Detalles Bibliográficos
Autores principales: Wang, Jie, Cen, Panpan, Chen, Jiajia, Fan, Linxiao, Li, Jun, Cao, Hongcui, Li, Lanjuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460333/
https://www.ncbi.nlm.nih.gov/pubmed/28583199
http://dx.doi.org/10.1186/s13287-017-0576-4
Descripción
Sumario:Liver failure is a severe clinical syndrome with a poor prognosis. Mesenchymal stem cell (MSC) transplantation has emerged as a new intervention in treating liver failure. It is conventionally recognized that MSCs exert their therapeutic effect mainly through transdifferentiation. Recently, published articles have shown that MSCs work in liver failure by secreting trophic and immunomodulatory factors as well as extracellular vesicles (EVs) before transdifferentiation. In particular,MSC-derived EVs have shown similar curative effects as MSCs. Here we review the role of MSCs as well as their derived factors and EVs in liver failure and discuss the use of MSC-derived EVs instead of intact MSCs in treating liver failure. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13287-017-0576-4) contains supplementary material, which is available to authorized users.

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