Role of mesenchymal stem cells, their derived factors, and extracellular vesicles in liver failure

Liver failure is a severe clinical syndrome with a poor prognosis. Mesenchymal stem cell (MSC) transplantation has emerged as a new intervention in treating liver failure. It is conventionally recognized that MSCs exert their therapeutic effect mainly through transdifferentiation. Recently, publishe...

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Detalles Bibliográficos
Autores principales: Wang, Jie, Cen, Panpan, Chen, Jiajia, Fan, Linxiao, Li, Jun, Cao, Hongcui, Li, Lanjuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460333/
https://www.ncbi.nlm.nih.gov/pubmed/28583199
http://dx.doi.org/10.1186/s13287-017-0576-4
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author Wang, Jie
Cen, Panpan
Chen, Jiajia
Fan, Linxiao
Li, Jun
Cao, Hongcui
Li, Lanjuan
author_facet Wang, Jie
Cen, Panpan
Chen, Jiajia
Fan, Linxiao
Li, Jun
Cao, Hongcui
Li, Lanjuan
author_sort Wang, Jie
collection PubMed
description Liver failure is a severe clinical syndrome with a poor prognosis. Mesenchymal stem cell (MSC) transplantation has emerged as a new intervention in treating liver failure. It is conventionally recognized that MSCs exert their therapeutic effect mainly through transdifferentiation. Recently, published articles have shown that MSCs work in liver failure by secreting trophic and immunomodulatory factors as well as extracellular vesicles (EVs) before transdifferentiation. In particular,MSC-derived EVs have shown similar curative effects as MSCs. Here we review the role of MSCs as well as their derived factors and EVs in liver failure and discuss the use of MSC-derived EVs instead of intact MSCs in treating liver failure. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13287-017-0576-4) contains supplementary material, which is available to authorized users.
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spelling pubmed-54603332017-06-07 Role of mesenchymal stem cells, their derived factors, and extracellular vesicles in liver failure Wang, Jie Cen, Panpan Chen, Jiajia Fan, Linxiao Li, Jun Cao, Hongcui Li, Lanjuan Stem Cell Res Ther Review Liver failure is a severe clinical syndrome with a poor prognosis. Mesenchymal stem cell (MSC) transplantation has emerged as a new intervention in treating liver failure. It is conventionally recognized that MSCs exert their therapeutic effect mainly through transdifferentiation. Recently, published articles have shown that MSCs work in liver failure by secreting trophic and immunomodulatory factors as well as extracellular vesicles (EVs) before transdifferentiation. In particular,MSC-derived EVs have shown similar curative effects as MSCs. Here we review the role of MSCs as well as their derived factors and EVs in liver failure and discuss the use of MSC-derived EVs instead of intact MSCs in treating liver failure. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13287-017-0576-4) contains supplementary material, which is available to authorized users. BioMed Central 2017-06-06 /pmc/articles/PMC5460333/ /pubmed/28583199 http://dx.doi.org/10.1186/s13287-017-0576-4 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Wang, Jie
Cen, Panpan
Chen, Jiajia
Fan, Linxiao
Li, Jun
Cao, Hongcui
Li, Lanjuan
Role of mesenchymal stem cells, their derived factors, and extracellular vesicles in liver failure
title Role of mesenchymal stem cells, their derived factors, and extracellular vesicles in liver failure
title_full Role of mesenchymal stem cells, their derived factors, and extracellular vesicles in liver failure
title_fullStr Role of mesenchymal stem cells, their derived factors, and extracellular vesicles in liver failure
title_full_unstemmed Role of mesenchymal stem cells, their derived factors, and extracellular vesicles in liver failure
title_short Role of mesenchymal stem cells, their derived factors, and extracellular vesicles in liver failure
title_sort role of mesenchymal stem cells, their derived factors, and extracellular vesicles in liver failure
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460333/
https://www.ncbi.nlm.nih.gov/pubmed/28583199
http://dx.doi.org/10.1186/s13287-017-0576-4
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