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Age dependent accumulation patterns of advanced glycation end product receptor (RAGE) ligands and binding intensities between RAGE and its ligands differ in the liver, kidney, and skeletal muscle

BACKGROUND: Much evidence indicates receptor for advanced glycation end products (RAGE) related inflammation play essential roles during aging. However, the majority of studies have focused on advanced glycation end products (AGEs) and not on other RAGE ligands. In the present study, the authors eva...

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Autores principales: Son, Myeongjoo, Chung, Wook-Jin, Oh, Seyeon, Ahn, Hyosang, Choi, Chang Hu, Hong, Suntaek, Park, Kook Yang, Son, Kuk Hui, Byun, Kyunghee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460364/
https://www.ncbi.nlm.nih.gov/pubmed/28592983
http://dx.doi.org/10.1186/s12979-017-0095-2
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author Son, Myeongjoo
Chung, Wook-Jin
Oh, Seyeon
Ahn, Hyosang
Choi, Chang Hu
Hong, Suntaek
Park, Kook Yang
Son, Kuk Hui
Byun, Kyunghee
author_facet Son, Myeongjoo
Chung, Wook-Jin
Oh, Seyeon
Ahn, Hyosang
Choi, Chang Hu
Hong, Suntaek
Park, Kook Yang
Son, Kuk Hui
Byun, Kyunghee
author_sort Son, Myeongjoo
collection PubMed
description BACKGROUND: Much evidence indicates receptor for advanced glycation end products (RAGE) related inflammation play essential roles during aging. However, the majority of studies have focused on advanced glycation end products (AGEs) and not on other RAGE ligands. In the present study, the authors evaluated whether the accumulation of RAGE ligands and binding intensities between RAGE and its ligands differ in kidney, liver, and skeletal muscle during aging. RESULTS: In C57BL/6 N mice aged 12 weeks, 12 months, and 22 months, ligands accumulation, binding intensities between RAGE and its ligands, activated macrophage infiltration, M1/M2 macrophage expression, glyoxalase-1expression, and signal pathways related to inflammation were evaluated. The RAGE ligands age-associated accumulation patterns were found to be organ dependent. Binding intensities between RAGE and its ligands in kidney and liver increased with age, but those in skeletal muscle were unchanged. Infiltration of activated macrophages in kidney and liver increased with age, but infiltration in the skeletal muscle was unchanged. M1 expression increased and M2 and glyoxalase-1 expression decreased with age in kidney and liver, but their expressions in skeletal muscle were not changed. CONCLUSION: These findings indicate patterns of RAGE ligands accumulation, RAGE/ligands binding intensities, or inflammation markers changes during aging are organs dependent. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12979-017-0095-2) contains supplementary material, which is available to authorized users.
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spelling pubmed-54603642017-06-07 Age dependent accumulation patterns of advanced glycation end product receptor (RAGE) ligands and binding intensities between RAGE and its ligands differ in the liver, kidney, and skeletal muscle Son, Myeongjoo Chung, Wook-Jin Oh, Seyeon Ahn, Hyosang Choi, Chang Hu Hong, Suntaek Park, Kook Yang Son, Kuk Hui Byun, Kyunghee Immun Ageing Research BACKGROUND: Much evidence indicates receptor for advanced glycation end products (RAGE) related inflammation play essential roles during aging. However, the majority of studies have focused on advanced glycation end products (AGEs) and not on other RAGE ligands. In the present study, the authors evaluated whether the accumulation of RAGE ligands and binding intensities between RAGE and its ligands differ in kidney, liver, and skeletal muscle during aging. RESULTS: In C57BL/6 N mice aged 12 weeks, 12 months, and 22 months, ligands accumulation, binding intensities between RAGE and its ligands, activated macrophage infiltration, M1/M2 macrophage expression, glyoxalase-1expression, and signal pathways related to inflammation were evaluated. The RAGE ligands age-associated accumulation patterns were found to be organ dependent. Binding intensities between RAGE and its ligands in kidney and liver increased with age, but those in skeletal muscle were unchanged. Infiltration of activated macrophages in kidney and liver increased with age, but infiltration in the skeletal muscle was unchanged. M1 expression increased and M2 and glyoxalase-1 expression decreased with age in kidney and liver, but their expressions in skeletal muscle were not changed. CONCLUSION: These findings indicate patterns of RAGE ligands accumulation, RAGE/ligands binding intensities, or inflammation markers changes during aging are organs dependent. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12979-017-0095-2) contains supplementary material, which is available to authorized users. BioMed Central 2017-06-05 /pmc/articles/PMC5460364/ /pubmed/28592983 http://dx.doi.org/10.1186/s12979-017-0095-2 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Son, Myeongjoo
Chung, Wook-Jin
Oh, Seyeon
Ahn, Hyosang
Choi, Chang Hu
Hong, Suntaek
Park, Kook Yang
Son, Kuk Hui
Byun, Kyunghee
Age dependent accumulation patterns of advanced glycation end product receptor (RAGE) ligands and binding intensities between RAGE and its ligands differ in the liver, kidney, and skeletal muscle
title Age dependent accumulation patterns of advanced glycation end product receptor (RAGE) ligands and binding intensities between RAGE and its ligands differ in the liver, kidney, and skeletal muscle
title_full Age dependent accumulation patterns of advanced glycation end product receptor (RAGE) ligands and binding intensities between RAGE and its ligands differ in the liver, kidney, and skeletal muscle
title_fullStr Age dependent accumulation patterns of advanced glycation end product receptor (RAGE) ligands and binding intensities between RAGE and its ligands differ in the liver, kidney, and skeletal muscle
title_full_unstemmed Age dependent accumulation patterns of advanced glycation end product receptor (RAGE) ligands and binding intensities between RAGE and its ligands differ in the liver, kidney, and skeletal muscle
title_short Age dependent accumulation patterns of advanced glycation end product receptor (RAGE) ligands and binding intensities between RAGE and its ligands differ in the liver, kidney, and skeletal muscle
title_sort age dependent accumulation patterns of advanced glycation end product receptor (rage) ligands and binding intensities between rage and its ligands differ in the liver, kidney, and skeletal muscle
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460364/
https://www.ncbi.nlm.nih.gov/pubmed/28592983
http://dx.doi.org/10.1186/s12979-017-0095-2
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