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Mitochondrial Cardiomyopathy Presenting as Dilated Phase of Hypertrophic Cardiomyopathy Diagnosed with Histological and Genetic Analyses

We report a case with 46-year-old man diagnosed with mitochondrial cardiomyopathy in the dilated phase of hypertrophic cardiomyopathy. Since cardiac magnetic resonance imaging, beta-methyl-p-(123)I-iodophenyl-pentadecanoic myocardial scintigraphy, and positron emission tomography/computed tomography...

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Autores principales: Kuno, Toshiki, Imaeda, Syohei, Asakawa, Yohei, Nakamura, Hiroshi, Takemura, Genzou, Asahara, Daisuke, Kanamori, Akira, Kabutoya, Tomoyuki, Numasawa, Yohei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460387/
https://www.ncbi.nlm.nih.gov/pubmed/28620551
http://dx.doi.org/10.1155/2017/9473917
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author Kuno, Toshiki
Imaeda, Syohei
Asakawa, Yohei
Nakamura, Hiroshi
Takemura, Genzou
Asahara, Daisuke
Kanamori, Akira
Kabutoya, Tomoyuki
Numasawa, Yohei
author_facet Kuno, Toshiki
Imaeda, Syohei
Asakawa, Yohei
Nakamura, Hiroshi
Takemura, Genzou
Asahara, Daisuke
Kanamori, Akira
Kabutoya, Tomoyuki
Numasawa, Yohei
author_sort Kuno, Toshiki
collection PubMed
description We report a case with 46-year-old man diagnosed with mitochondrial cardiomyopathy in the dilated phase of hypertrophic cardiomyopathy. Since cardiac magnetic resonance imaging, beta-methyl-p-(123)I-iodophenyl-pentadecanoic myocardial scintigraphy, and positron emission tomography/computed tomography revealed no remarkable findings, we performed electron microscopic examination, which aided in diagnosing mitochondrial cardiomyopathy. Muscle biopsy was also compatible with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes and DNA analysis also concluded it. Since muscle biopsy is less invasive for patients compared to endomyocardial biopsy, cardiologists need to consider it. The diagnosis of mitochondrial cardiomyopathy is helpful because it is a genetic condition and also for consideration of device therapy, as well as management for acute crisis.
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spelling pubmed-54603872017-06-15 Mitochondrial Cardiomyopathy Presenting as Dilated Phase of Hypertrophic Cardiomyopathy Diagnosed with Histological and Genetic Analyses Kuno, Toshiki Imaeda, Syohei Asakawa, Yohei Nakamura, Hiroshi Takemura, Genzou Asahara, Daisuke Kanamori, Akira Kabutoya, Tomoyuki Numasawa, Yohei Case Rep Cardiol Case Report We report a case with 46-year-old man diagnosed with mitochondrial cardiomyopathy in the dilated phase of hypertrophic cardiomyopathy. Since cardiac magnetic resonance imaging, beta-methyl-p-(123)I-iodophenyl-pentadecanoic myocardial scintigraphy, and positron emission tomography/computed tomography revealed no remarkable findings, we performed electron microscopic examination, which aided in diagnosing mitochondrial cardiomyopathy. Muscle biopsy was also compatible with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes and DNA analysis also concluded it. Since muscle biopsy is less invasive for patients compared to endomyocardial biopsy, cardiologists need to consider it. The diagnosis of mitochondrial cardiomyopathy is helpful because it is a genetic condition and also for consideration of device therapy, as well as management for acute crisis. Hindawi 2017 2017-05-23 /pmc/articles/PMC5460387/ /pubmed/28620551 http://dx.doi.org/10.1155/2017/9473917 Text en Copyright © 2017 Toshiki Kuno et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Kuno, Toshiki
Imaeda, Syohei
Asakawa, Yohei
Nakamura, Hiroshi
Takemura, Genzou
Asahara, Daisuke
Kanamori, Akira
Kabutoya, Tomoyuki
Numasawa, Yohei
Mitochondrial Cardiomyopathy Presenting as Dilated Phase of Hypertrophic Cardiomyopathy Diagnosed with Histological and Genetic Analyses
title Mitochondrial Cardiomyopathy Presenting as Dilated Phase of Hypertrophic Cardiomyopathy Diagnosed with Histological and Genetic Analyses
title_full Mitochondrial Cardiomyopathy Presenting as Dilated Phase of Hypertrophic Cardiomyopathy Diagnosed with Histological and Genetic Analyses
title_fullStr Mitochondrial Cardiomyopathy Presenting as Dilated Phase of Hypertrophic Cardiomyopathy Diagnosed with Histological and Genetic Analyses
title_full_unstemmed Mitochondrial Cardiomyopathy Presenting as Dilated Phase of Hypertrophic Cardiomyopathy Diagnosed with Histological and Genetic Analyses
title_short Mitochondrial Cardiomyopathy Presenting as Dilated Phase of Hypertrophic Cardiomyopathy Diagnosed with Histological and Genetic Analyses
title_sort mitochondrial cardiomyopathy presenting as dilated phase of hypertrophic cardiomyopathy diagnosed with histological and genetic analyses
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460387/
https://www.ncbi.nlm.nih.gov/pubmed/28620551
http://dx.doi.org/10.1155/2017/9473917
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